the wanting to eat might mean your seratonin levels have increased.
Have you tried taking half the dose half way through the day instead to see if that stops the fatigue? And reducing medication if you are feeling over medicated. If the b1 is working you might not need as much medication. Maybe take the b1 every day.
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B1 dose adjustment
B1
B1 
B1 and Vibrating gloves combination
B1 Thiamine 
