That said ... I watch, listen to and skim DOZENS of health videos weekly.
(Only leads to a LOT of confusion when doctors can't even agree if "meat" or "grain" is OK to eat!)
But while listening to this very good video, somewhere in the 'middle' (sorry I can't be more precise) -- this 2021 video doctor mentions a "new drug" (sorry again, I can't remember because I listen to these while in bed) ... that helps to stop the drug fluctuations.
"For instance, in PD, GI flora have long been thought to play a role in the metabolism of levodopa, the most effective PD pharmacologic treatment [141, 142]. Greater GI metabolism would theoretically reduce the amount of levodopa available to the brain, which could contribute to the dose failures often seen in advanced PD [143]. Recently, two reports have shown that several gut bacterial species do indeed harbor a tyrosine decarboxylase (TyrDC) enzyme that can metabolize levodopa [143, 144]. These bacteria reside in the small intestine where levodopa is metabolized, are found in the feces of people with PD, and correlate with levodopa dose and disease duration [143]. Furthermore, they are not inhibited by carbidopa, a drug co-administered with levodopa to block its peripheral metabolism [144]. However, S-alpha-fluoromethyltyrosine (AFMT), an amino acid that inhibits bacterial TyrDC, increased serum levels of levodopa in mice when co-administered [144]. While the clinical relevance of this observation is unknown, it demonstrates the potential of targeting a very specific function of the microbiome for therapeutic benefit."
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