A post-hoc analysis result from the PASADENA trial: Prasinezumab slows motor progression in rapidly progressing early-stage PD (preprint).

[jeffreyn]

"Here, we explore whether prasinezumab showed greater benefits on motor progression in rapidly [progressing] compared with more slowly progressing subpopulations of PD."

"In conclusion, prasinezumab showed a consistent numerical effect on slowing motor progression in subpopulations of individuals with rapidly progressing disease. A new Phase IIb study (PADOVA; NCT04777331) [is testing] the effect of prasinezumab on slowing motor progression in early-stage PD populations on stable treatment with MAO-B inhibitors or levodopa."

researchsquare.com/article/...

[redhawk1]

Was in this clinical trial for five years. From the conclusions drawn so far from the study it seems like that the Prothena experimental drug did at least have a positive effect on slowing the progression of the disease. If so, maybe the successive iterations of the drug can be improved and someday actually be an efficacious first line medication to battle this disease. Let’s hope it’s a step in the right direction!

[MarionP]

Actually very welcome information and news!