FMT Trial In Sixty-Eight Patients With Progressive Supranuclear Palsy (PSP-RS) Completed

[chartist]

This 2021 study showed positive results in people with PSP, a neurodegenerative disease :

thelancet.com/journals/ecli...

Here is a very relevant quote from the study :

' Efficacy analyses were performed on the intention-to-treat (ITT) analysis set. At week 16, the mean PSP Rating Scale (PSPRS) scores (the primary outcome) improved from 40.1 (SD 7.6) to 36.9 (SD 5.9) in the FMT group, whereas the scores changed from 40.1 (SD 6.9) to 41.7 (SD 6.2) in the placebo group, for a treatment benefit of 4.3 (95% CI, 3.2–5.4) (P < 0.0001). After 3-cycle intervention, symptoms of constipation, depression, and anxiety (the secondary outcome) improved significantly at week 16 in the FMT group compared with the placebo group, the majority of which were maintained at the 24-week follow-up (week 36). '

Again FMT shows benefit in another neurodegenerative disease other than PD and this one was also a randomized placebo controlled (RCT) study that showed significant benefit in terms of motor and non-motor symptoms.

Here is a link to the March 2023 FMT/PD study which also showed benefit in motor and non-motor symptoms of patients with PD:

ncbi.nlm.nih.gov/pmc/articl...

Here is a relevant study quote :

' Subjects with Parkinson's disease tolerated multi-dose-FMT, and experienced increased diversity of the intestinal microbiome that was associated with reduction in constipation and improved gut transit and intestinal motility. Fecal microbiota transplantation administration improved subjective motor and non-motor symptoms. '

Two main drawbacks to this study was very small size (11 patients) and transplant dosing that may have been too small. A positive to this study is that it was done in the US.

I am also waiting for the results of the Belgium study which used FMT in 40 PD patients in an RCT study and shows that it has completed this year(2023), but has not yet released the study results :

ichgcp.net/clinical-trials-...

Art

[Bolt_Upright]

I wish I had a snack bowl of frozen crapsules always available.

[chartist in reply to Bolt_Upright]

Well, hopefully that won't be such a far fetched idea before too long, Bolt! The trial that was just completed this year should be more revealing given the increased number of participants (40)!

Art

[Despe in reply to Bolt_Upright]