Scientists Figure Out How To Spawn New Neurons In Adult Brains

[Gcf51]

iflscience.com/scientists-f...

[Gcf51]

Link to study, Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells

science.org/doi/10.1126/sci...

[Bolt_Upright in reply to Gcf51]

Very interesting. Were you able to figure out how they reduced the MPC?

[Gcf51 in reply to Bolt_Upright]

Not me. I’m lost after 3 or 4 sentences of technical/medical jargon.

[Gioc in reply to Bolt_Upright]

QUOTE:

“We here used pharmacological MPC inhibition and genetic deletion of Mpc1 to assess whether a disruption of pyruvate import into mitochondria would affect NSPC maintenance, activation, and differentiation. Unexpectedly, we found that quiescent NSPCs express high levels of MPC and require pyruvate import into mitochondria for the maintenance of quiescence. Inhibition of MPC triggers their activation by increasing the intracellular pool of aspartate despite a substantial decrease of TCA cycle intermediates. Furthermore, conditional MPC1-knockout (cKO)NSPCs are able to differentiate into mature neurons, indicating a high metabolic flexibility, which allows these cells to adapt their metabolism according to substrate availability. We further show that this increased activation and undisturbed differentiation of MPC1-cKO NSPCs leads to an overall increase in neurogenesis in adult and middle-aged mice.”

However, reading certain studies like this makes me hungry.😁🐥😁

Pepsi, niacin , olive oil, pecorino romano e pasta Senatore Capelli.

[Zardoz]

"The ability to regenerate parts of the adult brain COULD have huge implications for the treatment of brain injury or disease, IF the findings can be replicated in humans. ..... ALTHOUGH STILL FAR IN THE FUTURE, leveraging reactivated NSCs to generate neurons to replace the ones that are lost is a promising avenue for further exploration...Professor Martinou. 'In the LONG TERM, these results COULD lead to potential treatments for conditions such as depression or neurodegenerative diseases.' " 

So much potential for the future that never comes.