A very informative video on resveratrol dosage breakdown.
I have never noticed any benefit from taking resveratrol but I dug it out of my pill collection and started a lower dose (<500mg) every other day to monitor long-term progress. 50 -100mg may be the target depending on your weight.
I'm a fan of anything safe purported to lower A1C and increase longevity. A big takeaway is that you may save your money if you've been taking a higher dose as recommended by Dr. Sinclair, which may be the reason I noticed no benefit in the past.
I think one of the problems with things like resveratrol (or pterostilbene, or co-q-10, or quercitin, or any of a zillion other antioxidant/anti-inflammatory type supplements) is that, if they slow the progress of your disease--and they might--such a thing would be very hard to measure in one person on a day-to-day basis.
After all, the lack of something (worsening) is hard to see, no?
That's really all I expect from those things. Which is why I wouldn't give them up, just because you don't catch any concrete benefit.
If you track with a glucose meter, say over a 3 month period as the video suggests to see if your fasting glucose gradually drop, then you'll know if you're impacting your A1C. Another way is to get a CBC/A1C and then track again after 3-4 months.
However, in most cases I hear what you're saying. In reality, it's often worse to supplement blindly than doing nothing as you can directly impact your macro mineral balance negatively if not careful, and over-supplementing antioxidants can deplete some of the vital essential metals if you're not tracking.
Ah. Yes, good point. I didn't watch the entire podcast--was more just commenting on the day-to-day "feeling better" aspects of any of it. One thing I think is a good idea though, and do, is cycle off my supplements for 1-2 week periods (which, when you think about it, is more like a day for a mouse.)
Are you tracking your A1c? I eat keto, so my blood sugar is quite low all the time. I'm not really taking any supplements for that, specifically.
I like to track new supplements' effects with FitBit Health Metrics that I find very useful. Depending on what a supplement is purported for, I definitely believe in pulsing or cycling while tracking. I also run regular bloodwork as well as HTMA to ensure the values don't fall out of range.
I used to track my glucose multiple times a day, especially during a very strict Ketogenic diet, but now I check only once in a while after fixing my Calcium/Magnesium "blood sugar" ratio along with Na/Mg that went out of whack during the keto after a while. Mineral balancing can become a challenge with a ketogenic diet, so be careful in the long run although you seem to be doing fine so far.
Keto diet means you intake an average of 70-80% fat from total daily calories by definition, depending on how hardcore you are and your ability to maintain ketosis, so the potential for micronutrients deficiency is indeed high. I noticed certain benefits of a short-term ketogenic diet (basically mock fasting) but in the end, it can really hurt your mineral balance in the long run if not VERY careful, in particular, Na, then K, Mg along with other trace minerals as the body starts processing electrolytes differently and alter homeostasis white sustaining on ketone. Google "ketogenic diet mineral deficiency" and you should get many hits.
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