Neuroprotective Potency of Neolignans in Magnolia officinalis Cortex Against Brain Disorders

[Bolt_Upright]

I had stopped taking my Magnolia Extract because I forgot why I was taking it. Thanks Sun_and_flowers for saving my old post and reminding me! Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway 2020 (Honokiol) healthunlocked.com/cure-par...

I did a check for new info and found this good article: Neuroprotective Potency of Neolignans in Magnolia officinalis Cortex Against Brain Disorders 2022 frontiersin.org/articles/10...

"Conclusion: Neolignans protect the nervous system from brain diseases including AD, PD, stroke, anxiety and depression mainly by protecting nerve cells and BMECs. It has the following effects on nerve cells:

1) regulating neuronal function mainly by normalizing neurotransmitters and their receptors

2) reducing neurotoxicity through reducing APP, γ-secretase, BACE1 and stabilizing αS native conformations

3) suppressing neuronal apoptosis through reducing the levels of Bax, caspase-3 and other apoptosis-related proteins

4) anti-inflammation in nerve by PPAR-γ/NF-κB pathway

5) anti-oxidation in nerve through MAPK pathway and PI3K/Akt pathway including p38/MAPK and MAPK/ERK.

The combined action of these pathways allows neolignans to have pleiotropic neuroprotective effects in different links. For BMECs, neolignans can increase blood supply, normalize blood glucose and close the connection between BMEC. In addition, neolignans also regulate the humoral environment by modulating the function of HPA axis, keeping the nervous system away from stress.

However, there are few reports on the neuroprotective effect of neolignans except MN (1) and HK (2). The overall pharmacological effect and mechanism of neolignans can only be inferred from the existing researches of MN (1) and HK (2). Furthermore, the clinical applications of neolignans are limited due to low bioavailability and quick metabolism, which should be paid attention to and improved. In summary, neolignans can be considered as a promising neuroprotective resource for the treatment of brain diseases, and more clinical studies are needed."

This is the brand I use. It is cheap and says it is 90% honokiol and magnolol. Swanson Superior Herbs- Magnolia Extract - Standardized swansonvitamins.com/p/swans...

[reedboat2]

great post, Bolt. Thanks- JG

[Sun_and_flowers]

Bolt_Upright, as a newbie, not yet knowing my way around the site made me miss this post, which I only saw this morning and finally had the time to read through just now.It looks really interesting and will see if I can buy the product.

Thank you! 🙏