Has anyone heard of this study?
Topaz study: Has anyone heard of this study... - Cure Parkinson's
Topaz study
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nature.com/articles/s41531-...
The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism
Zoledronic acid is a bisphosphonate. Bisphosphonates suffer from these sorts of adverse effects: aetna.com/cpb/medical/data/...
"The labeled warnings and precautions for zoledronic acid injection (5 mg) includes products containing the same active ingredient of zoledronic acid, hypocalcemia during treatment, renal impairment, osteonecrosis of the jaw, atypical femur fracture, and severe bone, joint and muscle pain. Zoledronic acid injection (5 mg) is contraindicated in hypocalcemia, patients with creatinine clearance less than 35 mL/min and in those with evidence of acute renal impairment. The most common adverse reactions (greater than 10%) include pyrexia, myalgia, headache, arthralgia, pain in extremity. Other important adverse reactions were flu-like illness, nausea, vomiting, diarrhea, and eye inflammation (Novartis, 2020)."
From my writing here: When Good Doctors Prescribe Bad Medicine: tinyurl.com/zvgcu79
"In other words, with high levels of K and D the hip fracture risk is only 67% (1/1.50) of the risk at low levels. In medspeak this is a hazard ratio of .67. Note how the data was framed as the dangers of low levels of vitamins rather than the benefits of high levels.
How about alleged improvement due to [bisphosphonate] Fosamax? According to this meta analysis, the risk ratio for hip fracture, according to some published studies, was .63-.65. For the other bisphosphonates it ranged from .58-.73. Even if these numbers are accurate, you will do as well with vitamins, without the risks."
did this study and finished it in sept 2022--- no problems and no broken bones