Parkinson’s disease stem cell therapy research update

[Farooqji]

In the stem cell field, there are some diseases where the road from research to therapy should be a relatively straight line. That seems the case for stem cells for Parkinson’s.

ipscell.com/2022/10/parkins...

[jeffreyn]

"Whether it is iPSC-based or ESC-based, autologous or allogeneic, I don’t know, but it’s going to happen."

Sure, but the unknowables are still the same:

- how soon;

- how expensive;

- how effective.

[Boscoejean]

There is no mention of Hope Biosciences clinical trials in this article

[jeffreyn in reply to Boscoejean]

Yes there is, but only indirectly.

"Many have unknown status, have been terminated, or are using MSCs or mesenchymal cells or bone marrow cells, which doesn’t make sense to me."

He is obviously not a fan of MSCs.

[Boscoejean in reply to jeffreyn]

Yes this seems quite evident. I guess he has not seen the reports by some of the participants.

[jeffreyn in reply to Boscoejean]

Do you have a reference for these reports that you could share with us?

[Boscoejean in reply to jeffreyn]

the preliminary results of the study have not yet been released but I have seen comments by a participant indicating that she has had improvements

[jeffreyn in reply to Boscoejean]

Is this Phase 2 study the study that you are referring to?

clinicaltrials.gov/ct2/show...

[Boscoejean in reply to jeffreyn]

yes

also this

clinicaltrials.gov/ct2/show...

[jeffreyn in reply to Boscoejean]

There is another Phase 2 study that is also due to finish in 2023. I think someone on this forum said that they were a participant.

clinicaltrials.gov/ct2/show...

[Boscoejean in reply to jeffreyn]

this site is sure difficult to search

healthunlocked.com/cure-par...

[Boscoejean in reply to jeffreyn]

I know someone who is a participant but I do not think she is on Health Unlocked

[Router_]

There is a large trial run by mayo for mesenchymal stem cells in msa. The earlier study had shown a dramatic decrease in progression, to the extent of a complete stop. I am quite convinced by what is seen in the earlier study data that this will become standard treatment in msa. Very strong signal for efficacy, remains to be seen how this translates to PD

[Farooqji]

freethink.com/health/stem-c...

[JohnPepper]

Why go to all that trouble and expense when you can do FAST WALKING every second day for a maximum of 1 hour and within two years you will be PD-FREE?