Demystifying Parkinson’s

[Farooqji]

Researcher details new findings as momentum builds behind treatment efforts: ‘Every problem looks intractable until it’s solved

news.harvard.edu/gazette/st...

[park_bear]

Very interesting interview.

" in this paper we’ve discovered that the very same part of alpha-synuclein that binds to membranes — the so-called N-terminus — has a double life and interacts with cellular machinery called P-bodies, a conglomerate of RNA-binding proteins in the cell that regulate the degradation of mRNA. So there’s a dichotomy: If you’re at the membrane, you’re not going to be in the P-body; if you’re in the P-body, you’re not at the membrane. "

Once again demonstrating aberrant alpha synuclein is the cause of Parkinson's:

" patients born with two extra copies of alpha-synuclein. In total, they have four copies of protein instead of just two. Those patients get a very aggressive form of Parkinson’s disease and dementia. "

[ddmagee1 in reply to park_bear]

Excellent analysis!

[jeffreyn]

See also this recent AlzForum article about this research.

New Role for α-Synuclein: Stabilizing mRNA in P-Bodies:

alzforum.org/news/research-...

[jeffreyn]

Although not directly related, this recent MedicalXpress article (posted by Gcf51 two days ago) could also be of interest.

Researchers uncover where and [how] proteins malfunction in Parkinson's disease:

medicalxpress.com/news/2022...