I'm early PD.
And I've been FIGHTING it ... daily... with various therapies.
Here's one of the most important: SAUNA
I have a home sauna and I'm in it at least 2 -3 times weekly for 90 minutes each session.
Here's some valuable research on 'HEAT' and 'AUTOPHAGY' that may very well have BIG benefits in the treatment of our PD!
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journals.physiology.org/doi...
HEAT THERAPY AND AUTOPHAGIC FUNCTION: IMPLICATIONS IN AGING AND CHRONIC DISEASE
"As mentioned previously, there is mounting evidence to suggest that dysfunctional autophagy is central to the pathogenesis of many diseases. For instance, neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease all involve the aggregation of toxic proteins that can normally be degraded via autophagy"
Autophagy and heat: a potential role for heat therapy to improve autophagic function in health and disease
"Autophagy is a crucial cell survival mechanism that involves the degradation and recycling of old or damaged organelles and proteins to maintain cellular homeostasis."
"Impairments in autophagy are central to the pathogenesis of many conditions including metabolic and neurodegenerative disorders, cardiovascular and pulmonary diseases, diabetes, and aging."
"In humans, our laboratory has demonstrated that ex vivo heating of whole blood for 90 min, clamped at temperatures of 37°C, 39°C, and 41°C, causes an increase in autophagic activity in a dose-dependent manner in peripheral blood mononuclear cells (PBMCs)."
"Therefore, targeting mild elevations in core body temperature (<41°C) for shorter durations (60–90 min) may present a feasible method to sufficiently stimulate autophagy through heat therapy."
Heat Shock Proteins
"Heat shock proteins (HSPs) are molecular chaperones that were originally named due to their observed accumulation in drosophila that had undergone various heat treatments (77). Since their original discovery, HSPs have been studied extensively, varying in size from 10 to over 100 kDa, and are known to repair and refold proteins damaged by heat or other proteotoxic stressors (78, 79)."
"HSP70 is of particular interest in the context of heat therapy, as it has consistently been shown to have beneficial effects on insulin signaling and suppression of proinflammatory cytokines, regardless of the tissue, and may be involved in the regulation of autophagy (26, 80, 81)."
".....the current evidence suggests that heat therapy may be an effective modality to stimulate both the autophagy and HSP systems concurrently."
"...heat therapy may provide a practical and relatively safe method of maintaining or restoring autophagic function in conditions with autophagic dysfunction."
Some promising evidence for fisetin in PD
