Check out Bumetanide for Parkinson

[Victor1975]

scienceofparkinsons.com/201...

[PDTom]

cureparkinsons.org.uk/2021/...

[park_bear]

Very interesting. Looks like investigators are working on new drugs for this purpose that do not have the diuretic effect. Unfortunately that means approval is a long way off. That said, this looks very promising - in a pilot study average improvement in part 3 of UPDRS was 11 points which is outstanding.

[Kia17 in reply to park_bear]

Sounds familiar? Taurine is doing the same without diuretic sides effects even with balancing electrolytes.Activating GAD and making more GABA out of Glutamate. I think Taurine is a wonder supplement.

[park_bear in reply to Kia17]

I take it is helping you? If so, how much did you take and for how long?

I had been taking one gram daily some time – over a month I believe – with no effect. It did not do any harm, so there is that.

[Kia17 in reply to park_bear]

I have started taking Taurine recently. It has helped me with endurance and strength , better muscle tone and converting glutamate to GABA noticing it with remarkable relaxation after workout. I take 500mg twice a day. I think there are more to it but need more time to confirm that.

[Godiv in reply to Kia17]

Taurine may be my next supplement to try. It sounds like you’re doing well with it. That’s great!

[Kia17 in reply to Godiv]

Yes. I think Taurine is an essential supplement for me.

[Godiv in reply to Kia17]

That’s good. I’m glad it’s working for you. Do you have any recommendations for brand or amount? And I realize what you’re taking may not work for me but I have no clue where to start. Thank you.

[Kia17 in reply to Godiv]

Thank you.I take Taurine from NowFood. 500mg twice a day.

[Godiv in reply to Kia17]

I like them. That sounds great thank you so much!

[Gcf51]

Lowering chloride lowers dopamine depletion and therefore decreases PD motor problems, Bumetanide produces a higher urinary Na+:K+ ratio with a lower pH than hydrochlorothiazide, but my hydrochlorothiazide should help to some degree too. Says bumetanide shouldn't be taken with lithium, but I am sure low dose would not be a problem.

Ugh... Do I feel better because of the hydrochlorothiazide that I have been taking for a week or Sublingual (B1) that I have been taking a week also?

[Smittybear7 in reply to Gcf51]

What is Bumetanide and where can you get it? How do you know how much to take? Thanks

[Victor1975 in reply to Smittybear7]

epiphanyasd.blogspot.com/20...

[Godiv in reply to Gcf51]

That’s OK Gcf51. You’ll figure it out at some point and as long as somethings working that’s wonderful!

[Smittybear7]

Thanks

[Victor1975]

"B&A Therapeutics has applied for an international patent for the use of a diuretic, Bumetanidev a blocker of the chloride ions importer NKCC1, in the treatment of Parkinson’s disease" batherapeutics.com/clinical...