Chlorogenic Acid Adverse, n=1

[park_bear]

Chlorogenic acid is a component of the coffee bean. There are favorable studies of its effect on Parkinson's in animal models. No interventional clinical studies that I know of.

Over a month ago I embarked on a personal trial of chlorogenic acid, 200 mg daily, taken in the morning. Over the ensuing weeks I noticed a gradual worsening of my motor impairment, objectively measurable as reduced hiking and rock scrambling ability. I was reluctant to attribute this to the chlorogenic acid, as I believed it ought to be helping. The last straw came 30 days in, when I felt obliged to take 4 doses of C/L 25/100 ER over the course of a day, instead of my usual 2 and 1/2 doses. In the 10 days since quitting I have experienced a gradual improvement, which confirms to me chlorogenic acid was the cause.

We are all different. What is true for me is not necessarily true for others. That said, I certainly will not be recommending this idea.

Chlorogenic acid was discussed here:

healthunlocked.com/cure-par...

[JCRO]

Good to know. Ty for the n = 1 study. 😬

[chartist]

I had also read good things about chlorogenic acid in human health, but had never gotten around to testing it yet

Art

[MarionP]

There you go, thanks for doing it.

[ElliotGreen]

Nice black swan illustration. Glad you recovered from the effects. Strange to think of foods or etc that some people with allergies unwittingly consume regularly that have negative effect. It's so good to pay attention to your body's responses to things.

[Boscoejean]

I am glad you brought this up

[enjoy2013]

Dear Park_Bear,I liked your post but I would not encourage you to take so much risk again, in the sense that I feel that you should have stopped earlier, once you observed you had lost physical fitness. (your) safety first!

[park_bear in reply to enjoy2013]

At the time, it was coincidental with a temporary interruption in my exercise regimen which could also have been the cause. So that ambiguity needed to be sorted out. It seems it is rarely the case that everything else in my life stays constant!

[enjoy2013]

Hahaha... I know what you mean!

[Gigi216]

I think I read years ago that it could block thiamine, I’ll see if I can find that information again

[Gigi216 in reply to Gigi216]

ift.onlinelibrary.wiley.com...

[House2]

I tried it had to stop, made my bladder issues much worse. N = 2 now