Excessive sweating

[Fed1000]

The moments when my PD is stronger are often preceded by excessive sweating. Does this happen to someone and is he able to give me an explanation?

[Gioc]

Ciao Federico, I understand your problem but I don't have an answer, maybe it's the swallowing-related musculature that becomes stiff. It happens to me too.

Thanks for the information about the book, I want to read it.

Acimipox is a form of synthetic vitamin B3 niacin, I am doing tests with normal niacin , nicotinic acid.

Gio

[Gcf51]

As I understand, PD causes Temperature Sensitivity, because your brain loses contact with body sensors (my explanation as to why). Temperature sensitivity is one of improvements I feel as a result of taking B1 as TTDF.

[Fed1000 in reply to Gcf51]

Thanks for the reply, it seems to me that it makes sense. I'm taking 300mg. of B1 (normal type) but with no benefit. Do you think that B1 as TTDF can change that or not since it is the same molecule?

[Gioc in reply to Fed1000]

Oops forse ho capito male , ho confuso sudorazione con salivazione 😄

Mi sa che sto peggiorando 😂😂

[Gcf51]

Fed1000 Do I think, Possibly Yes; I'm no doctor. According my calculation 50mg TTDF is 33.3mg of B1. TTDF has been proven to cross BBB, I don't know about the other forms. note as hcl does not unless maybe at high dose.

[Fed1000 in reply to Gcf51]

Fursultiamine (TTDF) crosses BBB while this does not happen for the other forms of Thiamine. I read that in Japan Fursultiamine is marketed under the name of Alinamin F and is used, as well as for energy supply, also as a supplement in some forms of Alzheimer's. It would be useful to knowif in that country TTDF was also used for PD.

[Gcf51 in reply to Fed1000]

"supplement in some forms of Alzheimer's. It would be useful to know if in that country TTDF was also used for PD." Really you found sometime I haven't. I have read that Asian country literature with chicken print types are hard for the western world to search through.

[Gcf51 in reply to Fed1000]

Do you have reference link to the info on Japan's use?

[Fed1000 in reply to Gcf51]

I just collected various information that I put together. It was synthesized in Japan in the 1960s from allithiamine. I can't find in Europe and I'm trying in Japan. I hope it's worth it. I see that on Amazon Japan there are various dosages. Which one do you recommend? Thank you very much.

[Gcf51 in reply to Fed1000]

I have not research a lot, I am making 2 half caps from one 50mg cap. I am taking walmart.com/ip/Allithiamine... The contents of the cap taste awful.

[Gcf51 in reply to Fed1000]

I found a link: drugs.ncats.io/drug/T3557LWB27 says fda approved.

[LAJ12345]

How does this symptom tie into your levodopa dosing? If the rigidity and the sweating occur at about 1 1/2 - 2 hours after taking a dose I believe it occurs at peak blood plasma so may indicate that your dose is too high. My husband found when he was taking a higher dose he would feel like his feet were on fire. Now his dose is reduced he doesn’t get the burning or the extreme rigidity any more.

[Fed1000 in reply to LAJ12345]

Thanks. My sweating is indipendent of the dosage and timing of taking Levodopa. I have sporadic episodes even at night. When sweating occurs the PD bites more: greater slowness, increased tremor.

[jackedmonston]

For several months I had serious night sweats requiring ten or more shirt changes a night. My PD doc said I didn’t need Carbidopa/levodopa at night. When I changed PD docs, the new one said I DID need Carbidopa/Levodopa at night if I was sweating like that. I still sweat, but change my shirt only two or three times a night?