Please read the whole paper - it is interesting. (I am not an expert in biology or biochemistry, but am excited about the information available). KINDLY SHARE YOUR THOUGHTS . I will leave it the experts here to provide any feedback.
QUESTION : Can NMN which is better than UROLITHIN (UA) - according to the paper - help stop PD if not cure it or at least alleviate symptoms?
(Given that PD is related to mitchondrial dysfunction and thePINK1-parkin-mediated mitophagy mechanism is not efficient or active )
Found a recent article (published Feb.18,2022) about UA and NMN - both mitophagy-inducing agents.
Conclusion is that both UA and NMN significantly stimulated PINK1-parkin-mediated mitophagy. But compared with NMN, UA COULD NOT ALLEVIATE PRION-INDUCED MITOCHONDRIAL FRAGMENTATION AND DYSFUNCTION AND NEURONAL APOPTOSIS.
From the article :
However, we found an interesting phenomenon that mitophagy activator UA, cannot alleviate mitochondrial fragmentation and dysfunction caused by PrP106-126, which eventually leads to cell apoptosis and decreased vitality. Based on reported studies [34], UA’s ability to prolong life and alleviate aging depends on mitochondrial function. We speculate that cells affected by prion disease have severe mitochondrial morphological fragmentation and dysfunction, so although UA can activate mitophagy, it also enhances damaged mitochondrial fragmentation. Then in that case, few functional mitochondria are left for UA to function in the neurons affected by the disease. Therefore, UA supplementation will not alleviate neuronal apoptosis and death caused by prion disease.
Another mitophagy activator, NMN supplementation could not only activate PINK1-parkin-mediated mitophagy in the prion disease cell model but also restore mitochondrial morphology and function, thereby alleviating neuronal apoptosis induced by PrP106-126, the therapeutic effect of NMN has also been reported in other diseases, such as premature aging-related ataxia telangiectasia and hypertension-related stroke [50, 51].
“Can NMN which is better than UROLITHIN (UA) - according to the paper - help stop PD if not cure it or at least alleviate symptoms”Disclaimer: I’m no expert either
From what I have learned from a lot of reading about this I believe that yes, NMN can at least help reduce the underlying pathology of PD.
Here's another question. Nicotinamide Riboside (NR) vs. NMN? This analysis comes from an extremely biased source, but it underscores how difficult it is to know which supplements to take.
I agree - not easy for people like us to be the judge.
I have given my mother TruNiagen for more than a year - both single and double doses per day and have not seen any PD symptoms being reduced ( tremor/constipation/gait/shuffling/sleep, etc. Have not tried NMN till now to make any judgement.
If my memory serves me right, Dr. David Sinclair(who is a reputed scientist working on aging and related matters) takes NMN and not Nicotinamide Riboside (not that it matters, but only FYI)
Ditto. Hubby has been taking NR for at least 2 years. Nothing spectacular, however, when he takes Niacin (flushing), he becomes more energetic. There a few NR caps left, and when hubby's finished, will start NMN and NA alternating them back and forth.
Yes, it is him that inspired me to try it. When I last had a round of it my energy was better and my nails got thicker than they had been. When I stopped, and started NR, approx a couple weeks later my energy decreased and about 2 months later it occurred to me that my nails were no longer thick. Coincidence maybe but I’ve just resumed NMN so we shall see.
Jim, we all know that not two PWP are alike. Hubby has been taking NR for a long time, no obvious benefits. I am glad it works for you! We have to share experiences with different supplements. That is how I learned about all the supplements/vitamins and their benefits or not.
There are no obvious benefits for me, either. I take it because early indications are that it might be beneficial in the long run.
In general, I tend to think of things which confer an obvious and almost immediate benefit as symptomatic relief. I think/hope there might be some compounds or remedies which address the underlying problems. PD takes many years to develop and it tends to progress very slowly. I hope TruNiagen, B1, B12, Neuroaspis slow that progression even further, but I don't take any of them expecting to feel immediate benefits. The only thing which confers an almost immediate benefit for me is Sinemet.
I also used TruNiagen for about 4 months with no noticeable effect. I'm taking 250 mg NMN/day, so far about two weeks in. Tough to know how much NMN is actually in the product as apparently there is a lot of scam NMN in the market.
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