Chinese M.D. has effective treatment for PD: Guo Teng herb

[PDWarrior1900]

Watch the Sept 2021 YouTube video of this Hong Kong M.D., Dr. Lin:

youtube.com/watch?v=T5xciWI...(Not working as expected?)

I'm still researching this -- but your feedback would be appreciated on anything to do with Chinese medicine and PD.

I don't know the recommended dosage, yet. But I found the supplements/herb here:

amazon.com/gp/product/B0733...

amazon.com/gp/product/B01M5...

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READ the encouraging 2018 NIH study here:

ncbi.nlm.nih.gov/pmc/articl...

Uncaria Rhynchophylla (Guo Teng)

The herb Uncaria rhynchophylla, part of the Rubiaceae family, is used in traditional Chinese medicine. Uncaria rhynchophylla extract is made up of alkaloids, rhinchophylline, hirsutine, hirsuteine, corynanthine, corynoxine, and dihydrocorynantheine [109,110]. The most widely studied and named neuroprotective compositions among the alkaloids are rhinchophylline and isorhynchophylline [111,112].

In addition, the neuroprotection effect of Uncaria rhynchophylla has been reported in an experimental PD model [113]. Shim et al. documented that Uncaria rhynchophylla reduced neuronal cell death and ROS production, restored GSH levels in PC12 cells in case of toxicity of caspase-3 and 6-hydroxydopamine (6-OHDA) cells, and reduced the neuronal loss in the substantia nigra dopaminergic rats induced by 6-OHDA [113,114]. In the 1-methyl-4-phenylpyridinium (MPP+) induced SH-SY5Y and 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse cell models, Uncaria rhynchophylla has been found to improve cell viability, attenuate dopaminergic neuronal significant nigra and striatum lowering, and inhibit heat-shock protein 90 and autophagy [115].

All these results, taken together, indicate that Uncaria rhynchophylla demonstrates neuroprotective activity through multiple mechanisms of neuronal defense against damage, which may be attributable to the beneficial combined action of the active compounds in Uncaria rhynchophylla.

These antioxidant compounds inhibit the anti-inflammatory effect by inflammatory mediation and the anti-apoptotic effect, modulating the event and preventing the activation of the caspase and decreasing ROS generation and improving the antioxidant protective mechanism.

Rhynchophylline is an alkaloid found in certain Uncaria species (Rubiaceae). However, recent studies revealed that isorhynchophylline can easily pass the BBB. These observations suggested that isorhynchophylline may be an anti-inflammatory substance used to treat NDs [116,117].

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READ about Dr. Lin's 2011 positive experiment PD results here:

asianscientist.com/2011/07/....

and this 2011 study shows the COMPLETE HERBAL FORMULA!

proquest.com/docview/206080...

3.2. Treatment Effects within Groups

The mean score of PDQ-39 single index, total UPDRS and other parameters with significant change are shown in Table 3. TCM (The Chinese Medicine) therapy significantly reduced the complications of therapy from 4.22 points at baseline to 3.36 points at 12 weeks and 3.22 points at 24 weeks (UPDRS Part IV;

The results of this study showed that JWLJZT, made from a Chinese herbal decoction, significantly reduced some non-motor complications in patients with PD under conventional medicine treatment. The major improvement was reflected by the reduction of score in UPDRS IVC which assessed gastrointestinal disorders, such as anorexia, nausea and vomiting, sleep disturbances, such as insomnia and hypersomnolence, and symptomatic orthostasis.

In conclusion, the 11-herb TCM prescription resulted in significant improvement in some non-motor complications of conventional medicine treatment and communications abilities in patients with idiopathic PD. Studies of the biochemical mechanisms by which JWLJZT affects PD could point the way to further advances and even better clinical treatment of PD. Also, studies with larger sample sizes are required which would have increased statistical power and would be able to better determine if JWLJZT can offer long-term control of PD and retard the progression of this disease.

[park_bear]

I tried Gou Teng and it caused me diarrhea at 4 g dose. Maybe you will have better luck.

I suppose I could give it another go with an extract. Corynoxine is soluble in ethanol, but not water according to a couple of sources. So an ethanol extract would be in order.

Another drug candidate in Gou Teng, Isorhynchophylline, was also reported to be soluble in ethanol: ncbi.nlm.nih.gov/pmc/articl...

Found a source and put some on order:

herbies-herbs.com/tinctures...

YouTube link worked okay.

[PDWarrior1900 in reply to park_bear]

you might want to check out the amazon links for gou teng... it's already prepared in both pill and liquid form

[Hmop in reply to PDWarrior1900]

Where can I find them, Please

[park_bear in reply to PDWarrior1900]

Merely being in "liquid form" is not good enough. The active ingredients are not all soluble in water but they are soluble in ethanol. Therefore a prepared liquid extract must have been done with ethanol rather than water.

[chartist]

Is this the video?

youtu.be/T5xciWImNKA(Not working as expected?)

Art

[PDWarrior1900 in reply to chartist]

yes