There's been recent comments on tobacco. Years ago I was researching MS and came on medical reports on the use of nicotine patches for PD. I didn't go deeper into it but never forgot it either. Now I'm wondering if I should try it. I'm against smoking. That's why I never tried pot smoking. I think my dad died of complications from smoking. I think that's why I didn't look deeper into nicotine. But with the idea it might help with cognitive function I'm willing to give it a try.
Can someone give me a primer on these patches? I assume they aren't prescription but I'm not sure. That's how ignorant I am about nicotine. How addictive might they be? What do I look for at the pharmacy? What's the mechanics of applying the patch? Where does it go? Is the arm better than the leg? What's it cost?
TIA,
kpo
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kaypeeoh
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High-dose transdermal nicotine in Parkinson's disease patients: a randomized, open-label, blinded-endpoint evaluation phase 2 study pubmed.ncbi.nlm.nih.gov/289...
"Conclusions: High doses of transdermal nicotine were tolerated, but our study failed to demonstrate significant improvement in UPDRS motor scores. Improvement in unblinded secondary outcomes (UPDRS-II, UPDRS-IV, doses of l-DOPA equivalents) suggest a possible benefit for patients treated with nicotine, which should be confirmed in larger double blind, placebo-controlled studies."
Instead of nicotine, I would rather very low dose, 1-2 mg, if donepezil. Similar method of action I believe.
These results suggest that nicotine as well as AChE inhibitors, donepezil and galantamine, prevent glutamate neurotoxicity through alpha4 and alpha7 nAChRs and the PI3K-Akt pathway.
I learned a lot about Choline that I used already, and also about Alpha GPC.Does anyone use Alpha GPC in their diet? My only worry is increased anxiety.
I scanned the video. Ho talks like he's on something. I need alpha gpc and uridinine phosphate and huperzine and I've already forgotten what else. I need to watch it again.
I stopped smoking and within 6 months had pd, I have looked into this and, I don't think the nicotine is protective, I think it's one of the chemicals in cigarettes
"I stopped smoking and within 6 months had pd....." I would suggest that proves the OP's point. Have you tried stopping again? My only concern is my own addictive nature. I'm addicted to caffeine and carbs and late-nite '70s tv shows.
I'm not kidding about 'my own addictive nature.' How much nicotine is in a patch? If I want to try a low dose can I cut up the patch and apply 1/4? In a book by Lee Child someone ingests narcotics by cutting a patch into pieces and sucking on one like hard candy.
I wish I knew. How do you assess brain function? I do crossword puzzles that are supposed to be challenging. Maybe I do better on them now than I did six months ago. Or I simply got better at playing the game. It bugs me that the author is British and uses a lot of English celebrities that I've never heard of for clues.
That's why patches might be safer. No tar or other chemicals, just nicotine. Nicotine is dangerous enough. Years ago nicotine injections was used to euthanize dogs and cats.
Having been a vet you already know this: nicotine, oxalate, caffeine, pyrethrins and other natural insecticides affect everything with a nervous system. You can't patent these natural compounds, what chemists do is synthesize them into drugs and chemicals they can patent, and then add natural neurotoxins to patented products without being required to disclose it. The chemical formulations are proprietary trade secrets.
What these compounds do is act upon neurohormonal cell receptors to either activate (excite) or deactivate (suppress) the cellular response. Think of the cell receptor as a padlock and the chemical compound as the key that either unlocks (opens) or locks (closes) the cell receptor.
When neurotoxic chemical compounds flood the open cell receptors long enough, a horrible death ensues.
(That's why my neighbors cattle died from spray drift poisoning. I could have been found laying in my driveway. My precious boys could have been playing in our front yard. I escaped immediate death - I didn't escape injury.)
Because these products contain multiple neurotoxic chemicals, it's hard to know which pathway to target in neurodegeneration. Based on my experience, it's seems reasonable to target all of them by selectively blocking the cell receptors with a competitive antagonist.
I think there's junk in the patches too, just a lesser evil.
If I cut the patch down to 1/4 will it still adhere to skin? There's a lot worse ways to euthanize. I tried Acetyl choline. It paralyzes the diaphragm without sedating. I only did it that way once. I gave the IV and she kept looking at me pleading for help as she worked her jaw trying to breathe. One client wanted to do it himself and had me mix up a sedative for him to calm dog before shooting him. But he missed the fatal spot and she jumped up and ran off into the desert. The dog found her way to my clinic three days later. I showed up that morning and she was waiting calmly by the door.
Very interesting. The younger "Farnon" brother did a tour of vet schools in 1985. I was on an emergency call and didn't get to see him speak. That "James" killed himself was not shocking. Studies show that death by suicide is higher in the veterinary field than medical, dental or chiropractic fields.
The updated version of the TV show All Creatures Great And Small is showing on local PBS. Less cartoonish than the original but the same stories from the books.
One story James was trying to pull a calf while the client's friend was talking about the former vet, Mr Broomfield. "Mr Broomfield had arms like a tree. He would have had the calf out long ago..."
Once I was asked to tranquilize a horse so his feet could be trimmed. He wouldn't stand still, kept pawing and snorting and kicking. . The ranch hand kept going on and on about Dr Zancanello, Dr Zank for short. He said "Old Zank coulda had the horse done in no time. Shoulda called old Zank insteada this guy." I tried a new combo; rompun plus ace. Didn't work. Then I called Old Zank for advice. . He said he's always used rompun plus ace and it always worked.
Then the farrier roped one leg and I gave more rompun plus ace. With the ranch hand holding the rope and me holding the horse so he didn't collapse, we got the feet trimmed.
Did you ever think on chewing nicotine chewing gums? I do it since several years. Especially when my diskynesias bother me, and that‘s happening several times a day…..I can‘t say it helps for a better cognition, but I just got tested a few days ago and was in most tests quiet good (not to tell better than the young, healthy students 🤣)….
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nicotine from e-cigs for PD
more random thoughts....
Ropinirple and tripping
Newbie here...
