Levadopa

[Curious_Fred]

208 years and still NO medicine that stops or improves Parkinson.. Levadopa discovered in 1910 used in 1960's for Parkinson. I'm impressed that researchers can keep a dangerous drug like levodopa as the leading treatment for Parkinson's for so long!!! when it does not even cure Parkinson's and after 10 years or so (I have 16), causes dyskinisia, cognative fogging, slow reponse and what they never tell you is Periferal Neuropathic pain (feet so painful you cannot walk etc(caused by nerve damage).

One leading Italian specialist prescribed Majuana (not a bad idea) but didn't work and not very main stream. Drugs (more of them) don't help.

Radio Pulse treatmen worked slightly for ten days. Now suggesting electrical stimulation (hmmm, I have DBS but they said no problem).

Any ideas? Any similiar experiences.

[Bfp69]

Sorry for you levadopa-caused troubles and just as frustrated. I don’t know if you saw my ealier post and I’m not suggesting you try what we have- getting off levadopa is extremely hard- but just some food for thought:healthunlocked.com/cure-par...

Good luck to you curious_fred!

[Bfp69]

Also, don’t know if you’ve seen this, but pretty fascinating:npr.org/sections/health-sho...

The concept of doing what gives you joy reversing symptoms- a compelling approach away from chemical treatment.

[House2]

youtu.be/c-MIFoY2ye8(Not working as expected?)

[Patrickk]

Bydureon (a.k.a., Exenatide), a repurposed Type 2 Diabetes drug is now in third-stage trials in UK for stopping Parkinson’s in its tracks — results expected 2024. Testing — mice, open label, double blind — has been going on since 2010 and it has been positive every time.

scienceofparkinsons.com/201...

According to a very sensitive test, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), 2/3 of Parkinson’s patients are supposed to be insulin resistant. IR may be treated with Bydureon (Exanatide). Just an angle that might get us one step closer to getting Bydureon.

cureparkinsons.org.uk/news/...

TO LATE FOR YOU CURIOUS FRED but a cure may be under way:

South Korean researchers have learned how to dial our cells back to stem cell stage -- and are now administering monkey stem cells to parts of their brains that are short on dopamine producing cells -- with the hope they will fill in and take over the job.

Started this before with stem cells from other monkeys and had some success I think until local immune systems attacked the foreign cells.

[Tex1]

andersonpodiatrycenter.com/... information about procedure for neuropathy and restless leg performed by this center.

[JohnPepper]

There is no medication available that reverses the progression of Pd. That being the case, it would be better for you if you looked at other known ways of reversing the progression of Pd, so that instead of slowly getting worse, even if you do get temporary relief for shorter and shorter periods with medication, with the walking you are slowly getting better.

One of the proven ways to reverse your symptoms is to start doing Fast Walking. You would start at a very low level of walking, as fast as you can, for as little as 10 minutes or less, every second day and slowly working up to 1 hour every second day. That gives your muscles a chance to recover.

I did that back in 1994 and by 1998, at the age of 64, I was walking at less than 7 minutes per K and most of my more serious symptoms were a thing of the past.

I was not cured but I have not taken any Pd medication since 2002. I am now 87 and still walking. This method of high intensity exercise that is maintained for an hour has been scientifically proven to produce a molecule in your brain that repairs or replaces the damaged brain cells, which then gives you more levodopa and therefore, less symptoms.

For more information either Google John Pepper, Parkinson’s or look at my profile on this website.

[Curious_Fred in reply to JohnPepper]

Thanks John, I agree, don't place your hopes on a medical cure!!! Fast walking or forced excercise (Ref Jay Alberts, Bas BLoem et al) has been proven to produce Dopemine JUST LIKE WHEN YOU take levadopa. Neurpathic pain causes immense pain in the feet so walking is a non starter, Cycling can have the same effect as walking. BUT I WOULD prefer not to have Neuropathic pain in the first place.Note of caution. No two people are alike and people respond in different ways, what works for one may not for another. ALWAYS seek personlised therapists to find the best for you. Forced exercise is normally effective in ,most forms of Parlinson's. WE see it at the European Therapy centre day in day out.

John is right you CAN take control of your Parkinson's, I have lived with it for 17 years and feel good (still working 14 hours per day). BUT Neuropathic pain is different and painful!

[JohnPepper in reply to Curious_Fred]

Thanks for your response. I'm sorry it will not work for you , but am glad you are able to cope with it in other ways.

[Sydney75 in reply to Curious_Fred]

Yes exercise is key, many folks hold off on meds for many years, however, some are like my HWP (severe back problems) and can not even attempt that kind of exercise without severe repercussions. Moving to exercise in the pool as it no weight bearing. He needs to work less, stressful kind of job. Tried 18 months of no conventional meds he felt awful, hoping for new treatments but really don't trust Big Pharma

[Zardoz]

Levodopa works until it doesn't, then it does harm. There is speculation that the reason it eventually does harm has to do with "increased iron accumulation in the brain's dopaminergic neurons."

news.uci.edu/2022/01/19/uci...