Role of Short Chain Fatty Acids in Neurol... - Cure Parkinson's

Cure Parkinson's

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Role of Short Chain Fatty Acids in Neurological Disorders

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sciencedirect.com/science/a...

19 Replies
Kev2 profile image
Kev2

This is precisely what I believed. But how to translate this into action for parkinsons? Any probiotics, supplements, foods?

JCRO profile image
JCRO in reply to Kev2

healthline.com/nutrition/fo... might help. Buckwheat, Amaranth and the like. Pseudocereals might/seem to help with PD (Laurie Mischley ND research due out March 22). Easy to add to soups. Or use rather than rice.

in reply to JCRO

But then there is the issue of high grain intake spiking insulin which is very detrimental.Increasing SCFA via vege intake is the best in my opinion.

in reply to Kev2

Foods yes! 😊. Foods as the foundation with maybe supplements and maybe probiotics. Too broad to answer in a comment. The best diet I have found by far is Dr. Terri Wahls.

JCRO profile image
JCRO

Buckwheat is a seed.

Also the article I linked actually states:

Buckwheat scores low to medium on the glycemic index (GI) — a measure of how quickly a food raises blood sugar after a meal — and should not cause unhealthy spikes in blood sugar levels (with supporting reference).

I’m not suggesting swallowing kilos of it at a sitting.

Buckwheat - LM’s best and latest advice for flattening the curve, slowing down the PD progression.

rescuema profile image
rescuema in reply to JCRO

I agree organic grains with resistant fiber and beta glucans are the best for SCFA and research supports this. When sprouted to remove phytic acid to improve mineral absorbability with improved fiber, even better. I rotate all my legumes/grains sprouts in proportion with sprouted brown basmati rice for safe resistant starch as I can’t deal with loads of veggies for oxalates and other anti-nutrients that plants use to defend themselves. I always use vegetables in rotation for polyphenols in addition to sprouted grains to maintain and not lose weight while exercising. Buckwheat is extremely high in oxalates so it does not work for me but may work for others in moderation. Spinach is the devil for me.

Sprouted barley and black eyed peas
in reply to rescuema

Rescuema, did you see my post about lectins and PD? I wonder your thoughts on that? Someone commented with research referenced in the video I shared.

Between the high carb content and lectins in grains, I’m still iffy! If anyone could convince me otherwise it would be you ! Have you worn a glucose monitor to see how the different grains effect you?

I really want to eat sprouted beans and grains but 😞 I really want to be convinced 😞 but I think I need to stick with veges (leeks, cabbage, asparagus, artichokes, all great for SCFA, ?)

And I just learned that grains and beans are a great source of spermidine and Spermedine looks to be bad news for PD

rescuema profile image
rescuema in reply to

Stick to veggies if you feel best with it and don't have a problem maintaining weight and don't experience problems in the long run. I have stated my view in the past that if you try to avoid every hyped antinutrient compound thought to be hazardous, you'll soon end up with nothing to eat. It's all about weighing the balance depending on your sensitivity and exposure. The older you get, the sensitivity may develop for you to recognize. I myself went full circle. I have discussed enough of sprouted grains and the reasons for them for SCFA, and there's no reason for you to be convinced by me.

in reply to rescuema

Lectins? Spermedine? Glucose elevation? These are compelling reasons based on solid science.

I wish it weren’t so.

rescuema profile image
rescuema in reply to

I used to battle glucose spikes when I was most careful avoiding carbs, and I was following all known nutritional "science" - I told you this and battled it for a few decades. I no longer have any blood sugar regulation problems and I believe it's because I have enough microbiome diversity and SCFAs to process the carbs with restored insulin sensitivity. I attribute this to eating sprouted grains along with food diversity, which also probably helped restore mineral deficiencies while boosting circulating nutrients. There's no "solid science" yet when it comes to individual optimal nutrition.

in reply to rescuema

There is science on the effect of lectins in the PD brain. My concern is that Recommending lectin foods to the PD population could be detrimental. I posted about this.

There is science about the effects of Spermedine.

I posted about that as well.

Recommending high spermidine foods to the PD population could also be detrimental.

I’m just genuinely concerned

I understand you are sharing your personal experience but I do wish you would look at the info I posted about.

You of all people Rescuema are literally the last person on here whose info I wish to dispute because I have learned so much from you and I’m so grateful to you. And I appreciate you SO MUCH! ❤️ You do so much for us!

But I am truly concerned about this.

I think my concerns are valid.

rescuema profile image
rescuema in reply to

It’s not that certain natural food items are bad but you should rather see it as some people may be metabolically blocked in certain pathways to see the associations of the outcomes in stats, not necessarily applicable for everyone for any given disease. Avoiding known inflammatory refined foods is simpler but when it comes to natural nutritious whole foods composed of varying spectrums of antinutrients and phytonutrients, unnecessary avoidance without testing for allergies and known sensitivities is rather draconian and the issue becomes more complex than simply avoiding X. Obviously you should take the portions into the account of of your overall macros to actually matter. Eating a cup of aged goat cheese everyday is different from eating some occasionally as a side/garnish.

in reply to rescuema

Rescuema, 😞 “draconian” hit me hard because I understand what you are saying.I used to be so easy going. Why am I being so draconian? Fear. It’s hard to admit it to myself let alone blurt it out online. I’m scared to screw this up when there is so much at stake. I’m only 46. If I was 65+ like most of these PWP I would chill out a lot more. I’m just hoping to make it to the age most PWP are diagnosed at. My Dad has stage 5 PD.

I was just reading Terry Wahls info. to remind myself. Level one you can have two servings a week of specific starches or grain/seeds. I was aiming for level 3.

Sincerely, thank you. ❤️

I love learning but I’m generally so worn out of trying so hard.

GrandmaBug profile image
GrandmaBug in reply to

I've been doing level three Wahls for almost two years, sometime falling back to level two. I have been so happy with the results. I also intermittent fast.

in reply to GrandmaBug

Me too!

rescuema profile image
rescuema in reply to

The guy who posted the video on lectin and l-dopa promotes his own book The Carnivore Code and cites a limited scope hypothesis published in 2013, basically opposing plant-based diets. This is not "solid science" and also don't forget that it's the myopic understanding of the limited solid "science" that led to the widespread use of glyphosate - the simple assumption that inhibition of the shikimic pathway doesn't impact humans, totally disregarding the importance of the microbiome's complex symbiotic role in human physiology in health and diseases. Look at where we're now with the drastic escalation of global health issues with compromised gut health/barriers with dysbiosis (where gluten, lectin, etc becomes a problem) and we're still in the infancy of our understanding of the human gut microbiome relationship despite the hugely skyrocketed studies in light of the debacle including widespread antibiotics use.

I have repeatedly stated that soaking, sprouting and cooking the grains remove antinutrients, and that includes lectin amongst others. If you already have gut dysbiosis, then yes you do need to go through a period of avoidance to address the gut permeability to avoid an autoimmune response and further inflammatory cascade. It's good to be aware of the potential harms of any compound which will prevent you from doing foolish/deadly attempts to eat raw kidney beans (see the links below), but that shouldn't translate to the avoidance of diverse nutritious foods containing some degrees of antinutrients for health in the long run, and beneficial gut bacteria will help breakdown many antinutrients in addition to providing important circulating nutrients. I was offering a shortcut based on experience and research, but it's totally up to you to adopt dispute or disregard it. I have certainly taken draconian measures to revamp everything in an attempt to heal and I wasn't trying to denigrate you in any sense. I understand your motives and I'm sure it's a lot to process but I care and worry that you're wearing yourself out at your pace so try to take it slower and let things sink in with thorough comprehensive/bilateral research on any given idea for bigger pictures before taking actions. There are many who use fear-mongering to promote extremely biased viewpoints for marketing, so always be vigilant and play a devil's advocate for the opposing views for thorough due diligence not to be swayed drastically.

💕

hsph.harvard.edu/nutritions...

ncbi.nlm.nih.gov/labs/pmc/a...

healthline.com/nutrition/di....

in reply to rescuema

I look forward to reading your links asapSoaking and sprouting sometimes only removes 50% of lectins according to Gundry.

I feel secure in the Wahls protocol because I have read so many personal accounts of it.

Thank you as always

❤️

rescuema profile image
rescuema in reply to

Gundry is a salesperson and I don't trust much of what he says with his extremely controversial ideas. Even Wahls had to revise her book to address the concerns of oxalates, etc, so check out her revised expanded edition if not already.

in reply to JCRO

Relative to other seeds or grains, buckwheat does score well on the glycemic index. (My mistake in referring to it as a grain. Quinoa is a seed, etc. Peanuts are beans, etc) But

SCFA can be increased by vegetables that are even lower on the glycemic index.

And buckwheat contains a lot of lectins and lectins are hypothesized to contribute to PD. I just posted about this if you are interested.