A much better explanation of calciums role in Parkinson's

[parkie13]

medicalnewstoday.com/articl...

Very interesting

[annmariebaird]

You always post the greatest article thank you

[Hidden]

Do or don't take calcium? I suppose the simple answer was what my doctor said. At my age, will not do me good.

[aspergerian13]

This seems just as important as the calcium finding:

"More recent studies have revealed that Parkinson's also affects brain cells that do not produce dopamine, which might explain why some of the symptoms are not movement-related."

[Greenday in reply to aspergerian13]

"Recent findings indicate that α-synuclein pathology spreads into the brain and can affect the peripheral autonomic and somatic nervous system. Indeed, monomeric, oligomeric, and fibrillary α-synuclein can move from cell to cell and can trigger the aggregation of the endogenous protein in recipient neurons. This novel “prion-like” behavior could further contribute to synaptic failure in PD and other synucleinopathies "

ncbi.nlm.nih.gov/pmc/articl...

[aspergerian13 in reply to aspergerian13]

I returned to they original press release URL a while ago. The quote I presented yesterday seems to have been removed. Shucks.

[aspergerian13 in reply to aspergerian13]

I just now revisited the url. The quote I called attention to is either back online or I missed it on my initial revisit.

[Gioc]

Title "Thiamine and oxidants interact to modify cellular calcium stores"

ncbi.nlm.nih.gov/pmc/articl...

[alexask in reply to Gioc]

Good find. Maybe that's why thiamine works. This site is like a virtual human supercomputer, with the members trawling the internet to see what might help. Of course we may pull up the odd rubber boot, but you may have found a very decent nugget of truth there.

[Gioc in reply to alexask]

The relation between calcium and thiamine is obvious for person like me that use so high dose since two years.Some things are empirically knows.

[KERRINGTON in reply to Gioc]

Hi, can you tell me the dose, and what you see the greatest benefit has been to you after 2 years. Thanks !

[Gioc in reply to KERRINGTON]

You can get many other informations in this site and other search " Dr. Costantini" and "thiamine".

[aspergerian]

Good find. If my memory is working , Costantini cites Lonsdale 2006 in at least one study.

A Review of the Biochemistry, Metabolism and Clinical Benefits of Thiamin(e) and Its Derivatives.

Derrick Lonsdale.

ncbi.nlm.nih.gov/pmc/articl...

[stepan13]

thank you. especially i enjoied the internal link medicalxpress.com/news/2017...

[Oceanwind]

Thanks for posting this interesting article. Does anyone know what this means in terms of ingesting calcium in our food? (which I thought we're supposed to do as we get older, to fortify our bones etc.) Does too much calcium shown concentrated in the brain mean too much in ingested from our diet? I actually worry that I don't have enough calcium in my diet already, as I've cut down on dairy because I gathered that milk and cheese was not so good for a PWP.

[parkie13 in reply to Oceanwind]

You can get lots of calcium from your veggies. I don't think that you can overdose by eating. I think that calcium supplementation might make rigidity worse, you can even get muscle cramps and deposits in your circulatory system