Benfotiamine

[amit74]

Does Benfotiamine penetrate into the brain or not? I see everybody says a different story. Some say it does. Others it doesnt and if doesn't, how come they say its helpful for Alzhiemers..

[Gcf51]

There does seem to be some conflict, but if "Powerful beneficial effects of benfotiamine on cognitive impairment and β-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice" academic.oup.com/brain/arti... , I would think so....

[Bolt_Upright]

Well this is interesting:

What Is Benfotiamine? Benefits, Uses, and More - WebMD

webmd.com › Diabetes › Reference

Jan 3, 2020 — Benfotiamine is a synthetic form of vitamin B1 that some people think may help with diabetes-related nerve damage and other conditions.

Benfotiamine - Uses, Side Effects, and More - WebMD

webmd.com › ingredientmono-1574 › ben...

Benfotiamine is similar to thiamine (vitamin B1), but is absorbed by the body better than thiamine. The body changes benfotiamine to thiamine.

[MarionP in reply to Bolt_Upright]

Well yes and no. Benfotiamine can collect in the adipose tissue to the point where it may become an overdose. And is what you can get from benfotiamine enough?

[amit74 in reply to MarionP]

But if Benfotiamine is toxic, there are trials of 300 mg daily for over 2 years atleast if you search on Google ... Thats a long long time...

[Bolt_Upright in reply to amit74]

So I was going to ask, why use benfotiamine if B1 is the same thing, but instead I Googled and found this: differencebetween.com/what-...

Benftiamine has "better" absorption by the body. Here's an idea (Dr Constantini's idea, not mine): Just take more B1.

I hate to say I think the real difference is you can't put a patent on B1.

Benfontiamine vs B1

[Gioc in reply to Bolt_Upright]

“Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects“

researchgate.net/figure/Ora...

[Bolt_Upright in reply to Gioc]

That is so cool and timely! I just jumped from 1000 mg to 1500 mg a few days ago and already feel better. (I have RBD. Not diagnosed with PD). Thanks GioCas!

[Gioc in reply to Bolt_Upright]

Ok! 😀👍

[MarionP in reply to amit74]

You are not going to achieve the doses required by those who had success from Dr. Costantini with benfotiamine. You would have to prove non-toxicity at up to 4 grams per day for many months. You have such proof or know of it?

[amit74 in reply to MarionP]

50 mg Benfotiamine equals 250 mg Thiamine Hcl roughly. 600 mg Benfotiamine would equal 3g Thiamine Hcl. But Thiamine Hcl at these doses penetrates the brain whereas Benfotiamine does not as much,very little... Thiamine Hcl requires a protein transporter at low doses and at high doses, it is absorbed in the intestine and the brain via passive diffusion. When one takes a 100 mg pill of Th Hcl, around 5-10 ngs is absorbed MAX. But my post asks if benfo penetrates the brain or not?

[MarionP in reply to amit74]

Well I do not know if benfotiamine penetrates the brain, but the idea behind the benefit of thiamine hcl is that thiamine DOES cross the bb barrier, and that is where it does its good work after all and where the deficiency in PD exists. If all benfotiamine can do is work in the periphery, how does that help the basic disease except for peripheral deficiencies and tremors, and how would one achieve with benfotthiamine the dose effect of thiamine hcl needed without toxic reactions from the benfothiamine? And how could benfo achieve benefit in the amounts needed inside the brain, inside the substanta nigra?

No, I do not have a lot of faith in thinking about benfothiamine for PD...and I would have to challenge anyone thinking otherwise, including you, to offer proof, not simple rhetorical arguments of deductive logic rather than inductive logic. Argument is not proof. Proof supports argument, but argument is useless unless it is confirmed by proof. Basic. The need for proof supporting your argument is justified I think. I cannot say that I am an absolute expert, but I have been around the block a few times, and I also know when my leg is being pulled.

Also, the main thrust in research now for the disease itself has to do with addressing the misconformation effects upon beta amyloid. That's the main thrust of work in the cause/effects of the disease itself. What would any form of B1 have upon that core problem? B1 is for symptoms, not the disease.

[Gioc in reply to amit74]

According to Bettendorff and his studies on mice, no! In my opinion, yes, but to what extent I don't know. My experience with thiamine hcl has made me understand that to have *immediate* benefits in PD symptoms it takes a peak dose and it takes a minimum of 1000mg thiamine hcl of good quality, not old, in a single dose. Benfothiamines have different pharmacinetics, are more recent discoveries and appear to have some undesirable effects. (read review on Amazon or others)

[Gioc in reply to Gioc]

When it comes to vitamins, studying and understanding pharmacinetics is important; the distribution in the body may not be uniform and there may be localized deficiencies especially in the presence of passive diffusion. Injections intramuscolar of thiamine Hcl are of more predictable outcome.