The Effects of Magnesium – Melatonin - Vit B Complex Supplementation in Treatment of Insomnia

[JayPwP]

ncbi.nlm.nih.gov/pmc/articl...

The results of this study demonstrate that supplementation with Magnesium-melatonin-vitamin B complex for 3 months has a significant positive effect on sleep disturbances and is highly effective for the treatment of patients with insomnia. Regardless of the insomnia aetiology, Magnesium-melatonin-vitamin B complex supplementation reduces insomnia symptoms, as well as its consequences, thus improving the patients’ quality of life and preventing potential unwanted clinical, social, economic, or emotional repercussions.

[JayPwP]

So B complex + C complex + Melatonin safe together?

[chartist]

I wrote a little about this subject, Jay. Melatonin magnesium and zinc work well together and some melatonin supplements have B-6 in them to help absorption and add to the sleep effect. Here is a link to what I wrote:

healthunlocked.com/cure-par...

Art

[JayPwP in reply to chartist]

Thanks Art

[jeeves19 in reply to chartist]

Art. I thought that iron/zinc were not advised with Parkinson’s due to the negative additional contribution they can make to oxidative stress?

[chartist in reply to jeeves19]

I don't believe I brought up iron at all. PwP have a tendency toward zinc deficiency. Zinc can act as a pro-oxidant if too high or too low, but when the level is in range, zinc acts to reduce inflammation and reducing inflammation can reduce oxidative stress caused by the inflammation. So zinc acts as an antioxidant and reduces inflammation when the level is brought in range.

ncbi.nlm.nih.gov/pmc/articl...

hindawi.com/journals/omcl/2...

Too much and too little is detrimental for PwP, but you have to also keep in mind that the study I linked to in my post above , that study for melatonin/magnesium/ zinc for sleep only used 11.25 mg/day of zinc.

Art

[jeeves19 in reply to chartist]

Thanks bro. I presumed that zinc was in the same family as iron.

[chartist in reply to jeeves19]

I guess you could say they are somewhat related in so much as they both compete for absorption in the intestines.

Art

[Patrickk]

I would be leery of B6 or anything containing a dose of B6 (B complex). I have read that 200 mg dose of B6 is considered toxic and can cause permanent nerve damage -- most B6 supplements seem to contain 100mg (daily need; 1 1/2mg).

Link below to long, much of which impossible to read article by bio chemist who found his golf game and much else going downhill upon taking B complex. Very readable end. He finally figured out that B6 undoes the work of the Carbidopa part of Carbidopalevedopa -- which makes sure the levadopa goes to your brain where it makes dopamine, instead of being wasted (for PWP) elsewhere.

journeywithparkinsons.com/2...

[JayPwP in reply to Patrickk]

Thanks

[Despe in reply to Patrickk]

L/C has to be taken 2 hours apart from B6. A dose under 50mg of B6 is safe, I believe.

[Patrickk in reply to Despe]

L/C should be taken 2 hours after eating protein. Protein jumps the line in front of L/C on its way to wherever either of them go (usually only 1 hour with me).

But, that leaves the issue of B6 interfering with the "L" part of L/C unresolved. I figure I'll get all 1 1/2mg of B6 anyway -- not a huge need -- so why take chances.

Of course if you are using B6 in conjunction with some "tricky" treatment, maybe there's a reason to risk -- I doubt it.

[Despe in reply to Patrickk]

Absolutely, L/C should be taken either an hour before a meal or two hours after a meal. Here is my husband's schedule of meds:

Thyroid meds. Waits an hour and takes liposomal Glutathione and Vitamin B12. He then takes L/C (1/2 t) with MP (2-3 capsules). Two hours later, he has his breakfast after he takes his digestive enzymes, Betain HCL and probiotics. After breakfast, (no animal protein), he takes his fat soluble supplements plus B-complex with 25mg B6.

[Patrickk in reply to Despe]

Uh, shouldn't we be saying C/L, not L/C -- presumably for Carbidopalevedopa? 😀 Just to make sure I'm on the right page.

i don't know how much 25mg B6 might interfere with the action of Carbidopa (explained above).

[faridaro in reply to Patrickk]

A few years ago I've overdosed on just 25mg/day of B6 which was a part of B-complex. When I realized that neuropathy in my toes was spreading to the soles of my feet I got prescription for a blood test which revealed that my level of B6 was triple normal range.

[NellieH]

Is there a single supplement that combines the three? The article says nothing about dosage or timing. I find it somewhat confusing.

[ccr69]

I must have a totally different metabolism to other people because when I take Melatonin in any form it just keeps we awake all night.

[faridaro in reply to ccr69]

I have a friend who uses only liquid melatonin as other versions have no effect on her.

[chartist in reply to faridaro]

faridaro,

A forum member just mentioned over the weekend that she gets good effect from melatonin lozenges and little if any effect from melatonin capsules.

Art

[faridaro in reply to chartist]

Good to know Art. I was not aware of lozenges but personally also like sublingual version and currently use Superior Source melatonin dissolvable tablets which work well most of the time.

[Hidden in reply to faridaro]

That was me with the capsules vs. lozenges. The lozenges are sublingual, by the way (Source Naturals brand) and also contain some B6.

I've also had good results with the liquid by the same manufacturer. The capsules were a different brand, and I'm not sure if I'd have the same result with all capsules or just that one (haven't had enough time to experiment yet).

[Hidden in reply to ccr69]

That happens to me when I have too much.