Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease 2021

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Interesting stuff. That osteocalcin (OCN) looks useful, but so does proprionate.

Here is the full study:

microbiomejournal.biomedcen...

The finding in our study demonstrated that OCN increased the microbial propionate production, which might activate FFAR3 in enteric neurons, to exert its protective effect on PD. Using a mouse model of 6-OHDA-induced PD, the current study demonstrated that OCN can prevent motor impairments and dopaminergic neuronal loss in PD mice. Our data further suggested that OCN can exert protective effect via regulating microbial metabolism of SCFAs and increasing gut microbiota-derived propionate levels in PD mice. Furthermore, the oral administration of propionate showed protective effect against PD, suggested that microbial propionate production was a potential target for PD intervention. And our data suggested that propionate mainly acted on FFAR3 in enteric neurons to exert its neuroprotective effects on PD.