How long before levodopa stops working in Parkinson’s disease?

[Farooqji]

After taking levodopa for some time, typically a few years, patients may begin to experience a wearing off period, when symptoms return before it's time for their next dose of levodopa. This is also referred to as "off time.” Off time is common, and according to patient surveys, around half of patients who take levodopa report experiencing wearing off periods. Of those patients, 25% experience it 3 to 6 hours per day, and 52% have symptoms for 1 to 3 hours a day.

antidote.me/blog/how-long-b...

[laglag]

Good article. This article might be helpful to @ Lwpd

[Hikoi]

This article annoys me. Its heading leads you to believe that levadopa stops working. That is not true. Saying that levadopa doesnt work for as long is different from saying it stops working,

It then goes on to mention other drugs giving a false idea that we can pick and choose.. it gives the impression that other drugs could replace levadopa in fact except for agonists the place of the other drugs is to enhance levadopa’s action.