Metformin - if you are taking Metformin, can you please share how it is going?

I have read that the diabetes med, Metformin helps us, PWP. Please share if you have experience or info on this.

[WinnieThePoo]

Is this on your radar yet?clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

[Hidden in reply to WinnieThePoo]

Thank you. I had not seen that.

[WinnieThePoo in reply to Hidden]

Sorry. My post formatting wasn't great (on my mobile phone)

"That" was 2 different phase 2 trials of 2 more glp1 receptor agonists (like Exanatide / Bydureon) , both due to report in September this year

[Hidden in reply to WinnieThePoo]

I had failed to notice that there are two links. Thank you for introducing me to these trials.

I do wonder if the modest benefits one can potentially reap from exanatide can be replicated by having our brains rely on ketones instead of insulin.

In a video, Prof Roger Barker briefly mentioned “nicotine patch” and aspirin bc it is anti inflammatory.

I want to resume my research of nicotine and may try a patch.

Have you tried nicotine for PD? I thought it was preventative and that ship has sailed for us but perhaps not.

A function med doctor said he could prescribe metformin for me and I was perplexed as to why I would want metformin which is why I posted about it.

[WinnieThePoo in reply to Hidden]

(In reverse order, quickly)

I haven't tried metformin. I am wary of functional medicine practioners (wary, not hostile)

I haven't tried nicotine, although I've been sore tempted to have a cigar at Christmas , since reading about it. Preventative means prevents further progress of the disease - prevents the damage mechanism damaging more. That ship definitely hasn't sailed for us

As for natural anti-inflammatories - I take high strength curcumin (Turmeric). Impossible to know really whether its working for my PD, but my wife gave it a try too and it has visibly dealt with the arthritis in her hands. Careful with aspirin - even low dose

mayoclinic.org/diseases-con...

Ketones as a substitute for glp1 receptor agonists? I'm rusty, and the jacuzzi beckons, but I presume that is linking the PD neuron protection to the diabetes aspect of the drugs, whereas that video I linked with the presentation from Dr Arthuda explains that neurons have the same receptor as pancreas cells - a glp1 receptor (about 6 minutes in) and exanatide protected those pancreas cells dieing through its agonist action on those cells.

youtube.com/watch?v=vzz_kPu...(Not working as expected?)

[Hidden in reply to WinnieThePoo]

I need to rewatch that video. Despite watching it months ago I did not retain the info. Side note; Personally, my brain functions better when in a state of mild ketosis.

Turmeric has helped my Moms arthritis as well and my father who has PD improved slightly and his doctor attributes the improvement to the turmeric / curcumin.

I’m wary of functional medicine practitioners as well but I am also wary of my GP and neuro who have both given me some terrible advice. GP, “drink orange juice.” And prescribed sleeping pills that cause dementia. Neuro, “diet has no effect on PD.”

Thank you again for the links

[pdpatient]

@cclemonade. Very interesting, but where did you read it? The only thing that this continues to incrementally attempt to substantiate is that there is a link between diabetes and Parkinson's 😂.

BTW, I disagree. I should know 💁‍♂️🙄🤔

The only thing I can say is that it actually is a long term annoyance. Metformin causes Vitamin B 12 deficiency in the long run and because B 12 causes similar kind of symptoms like Parkinson's, it often leads to misdiagnosis.

RKM

[Hidden]

Parkinson’s News Today, coincidentally has a post today discussing Metformin.