CiteEffects of Helicobacter pylori on Levodopa Pharmacokinetics

[Farooqji]

The prevalence of Helicobacter pylori in Parkinson’s disease patients is reported to be about 1.6-fold higher than in a control population in some studies. Helicobacter has therefore been assumed to be linked to Parkinson’s disease, but the mechanism is unclear. As regards symptoms and treatment, patients with Parkinson’s disease on levodopa therapy and with Helicobacter pylori infection display worse motor control than those without Helicobacter infection. Eradication of the infection improves levodopa response in Parkinson’s disease, likely as a consequence of an increased oral pre-systemic bioavailability of levodopa, likely to be explained by reduced Helicobacter-dependent levodopa consumption in the stomach. In addition, small intestinal bacterial overgrowth may also have an impact on the therapeutic setting for levodopa treatment but is less well established.

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[Resano]

Malabsorption, constipation, B6 interference, gut bacteria, and now Helicobacter Pylori...

Hence the interest in high-dose thiamine and mannitol.

[Marcia123]

I have Sibo and believe that the levodopa exacerbates the silo. Should I try to get rid of the silo before taking the levadopa.? I am losing too much weight