Looking for advice on changing meds. PD Diagnosed 6 yrs ago at 57 yrs old. No meds for the first 3 yrs, and then started C-L , first 3x day.....and now 4x day.
Exercise 5x a week, taking B1 for 2 years.
Wearing off in 3.5 hours...Dr. wants to add Rasagaline. Any suggestions?
Paul
My experience with the MAO-B inhibitors including Rasagaline is they help slightly. No adverse effects experienced.
My husbands Neuro added in Rasagaline to help stop the Dopamine being broken down after 4 years on CL. Any increase in CL seemed to give dyskinesia and not really increase his movement.
It definitely helped but had to add in slowly. Still had dyskinesia so added in Amantadine. Now has been able to gradually decrease CL so takes less than 4 years ago.
It seems like trial and see with the PD drugs but now seems to be ok with current regime.
He takes B1 and has done for a couple of years.
Thanks
I’ve taken Rasagiline for at least 5 yrs. as an adjunct to Rytary. Also B1. See if it makes a difference. To be honest I’m not sure it helps.
My experience mirrors parkbear's: a bit of benefit and no adverse effects
To my understanding Rasagaline and C-L have different purposes.
My neurologist put me on Azilect (Rasagaline) when I was initially diagosed to slow progression and I have had minimal progression (knock on wood) in six years. Rasagaline had little effect on symptoms, but slowing progression is enough reason for me.
He put me on C-L for my tremors... first 3x day.....and now 4x day. I have 'played around' with when I take it versus when I eat to optimize its effectiveness. 4 times a day worked better for me.
We (my neurologist and me) recently added Nortriptyline 20 mg before bedtime to deal with a PD excess saliva symptom I have. It also helps me sleep and recent studies indicate it may also slow progression.
I have been on rasagiline for three years because my neuro said it would slow things up. hard to say if it has as i don't know what i would have been like without it. no side effects - take one tab every morning. 8.5 years since diagnosis, and mainly you wouldn't know i had pd. 😀
Is that all you take?
No way!!!! I take 6 siminet 12.5mg per day in three doses, 1 resagiline, 1 rotagotine 4mg patch each 24 hours, 2000mg B1, 1 x magnesium and 1 x cbd oil. I am thinking of adding murcuna but will see what Roy Propsner has to say as he seems very knowledgeble in the B1 protocol. I also have 40mg of propranalol for anxiety. Hope this helps. The B1 was definitely the most successful as the official PD drugs helped to a certain extent but B1 was brilliant.
That's very encouraging about the B1. What do you do for the evening to sleep?
Cbd oil is quite good
I also started C-L at 3x day, now at 4x day and off times after 3.5 hrs. My Neuro just started me on Rasagaline in January that I take 1x day. I have no side effects but still have my off times after 3.5 hrs. I take it first thing in the morning but considering switching to evenings. Still early but feel like it's not helping!
Seems safe according to posts....who knows what helps?
I'm very perplexed ?
When to combine thiamin and prescription meds
500 MG of thiamine joy
sole of feet numbness upon first getting out of bed in the morning
MUCUNA IS THE ONLY 'MED' I'M ON. Am I being naive ?
