Possible conflict of Korean Herbal laxative and L/Carb

[Sapeye2020]

I was given some of a Korean roots and a few berries by my Korean acupuncturist to ease my constipation. Next morning every thing was back to normal . I asked what the laxative component was and she said Chinese Peony or

from wiki : Glycyrrhiza uralensis (G. uralensis), also known as Chinese licorice, is a Traditional Chinese Medicine (TCM) that has been used in the clinic for centuries. Its functions include regulating drug properties, improving spleen function and blood circulation and reducing cough.

from

Molecular Medicine Reports:

Several CYP isoforms were differentially modulated depending on the specific compound and dose tested. In conclusion, the present study suggested that G. uralensis influenced the expression and activity of CYP450 enzymes. Therefore, caution should be taken when G. uralensis is co‑administered with drugs that are known to be metabolized by CYP450. This study contributed to the knowledge of the mechanis

Bioactive components of Glycyrrhiza uralensis mediate drug functions and properties through regulation of CYP450 enzymes

Several CYP isoforms were differentially modulated depending on the specific compound and dose tested. In conclusion, the present study suggested that G. uralensis influenced the expression and activity of CYP450 enzymes. Therefore, caution should be taken when G. uralensis is co‑administered with drugs that are known to be metabolized by CYP450. This study contributed to the knowledge of the mechanisms by which this medicinal plant, commonly known as licorice, modulates drug efficacy.

Question Is CYP450 and L/C compatible?

[park_bear]

CYP450 interaction is NOT the major dose limiting toxicity:

Wikipedia

en.wikipedia.org/wiki/Liquo...

" Its major dose-limiting toxicities are corticosteroid in nature, because of the inhibitory effect that its chief active constituents, glycyrrhizin and enoxolone, have on cortisol degradation, and include edema, hypokalaemia, weight gain or loss, and hypertension.[30][31] The United States Food and Drug Administration believes that foods containing liquorice and its derivatives (including glycyrrhizin) are safe if not consumed excessively. Other jurisdictions have suggested no more than 100 mg to 200 mg of glycyrrhizin per day, ...Liquorice should not be used during pregnancy.[6] … An increase in intake of liquorice can cause many toxic effects. Hyper-mineralocorticosteroid syndrome can occur when the body retains sodium, loses potassium altering biochemical and hormonal activities.[35] Some of these activities include lower aldosterone level, decline of the renin-angiotensin system and increased levels of the atrial natriuretic hormone in order to compensate the variations in homoeostasis.[36] ... Some other symptoms of toxicity include electrolyte imbalance, edema, increased blood pressure, weight gain, heart problems, and weakness. Individuals will experience certain symptoms based on the severity of toxicity. Some other complaints include fatigue, shortness of breath, kidney failure, and paralysis.[37][38] ...It is difficult to determine a safe level, due to many varying factors from person to person. In the most sensitive individuals, daily intake of about 100 mg GZA [glycyrrhizinic acid] can cause problems.[39] ... However, in most people, they can consume up to 400 mg before experiencing symptoms. A rule of thumb is that a normal healthy person can consume 10 mg GZA a day.[40]"

The amounts you would need to work as a laxative would probably exceed the above limits. Small amounts do help Parkinson's a little. See my writing here:

tinyurl.com/y9mjdhjt

To remedy Parkinson's constipation I use high-dose vitamin B1 to restore normal peristalsis, and high-dose vitamin C to restore normal moisture.