Ecstacy and Seratonin

[ladya2020]

There was a post a few days ago with a video that showed a young man who discovered his PD symptoms disapearred after he took the illegal drug Ecstacy and researchers did some tests to try and discover how it was affecting his brain. Can anyone point me back to it?

[CaseyInsights]

Here it is on you tube

youtu.be/FfP-cUTER5c(Not working as expected?)

[ladya2020 in reply to CaseyInsights]

Has there been any followup from these researchers?

[CaseyInsights in reply to ladya2020]

Now researching this. Find it intriguing 🧐

So do look rescuema post lower down this thread for a deep dive into the issue. 🌺

[ladya2020 in reply to CaseyInsights]

I found this online which is a follow up but I don't know how old it is.

scienceofparkinsons.com/201...

[park_bear in reply to CaseyInsights]

Thanks, Casey!

Summary:

Interesting part starts at minute 15. Ecstasy relieves Tim's levadopa induced dyskinesia, but not practical for regular use. It also relieves his immobility like levadopa but without increasing his dopamine. Research in progress.

Also subthalamic nucleus overactive in PD, and its malfunction can cause dyskinesia like symptoms.

[CaseyInsights]

... and here the full thread in which the video appeared

healthunlocked.com/parkinso...

[rescuema]

Posted this recently under the magic mushroom thread -

""Long term use of MDMA results in long-lasting serotonergic dysfunction and severe (50 to 80%) reductions in levels of serotonin in the brain...But more importantly for people with Parkinson’s disease, MDMA also causes dysfunction in the dopamine system of the brain, potentially making a bad situation worse for people with Parkinson’s disease."

scienceofparkinsons.com/201...

[ladya2020 in reply to rescuema]

Yes I found this online also and it is certainly not advocating the use of MDMA but about the development of something that mimics the same good effects for dyskenesia.

scienceofparkinsons.com/201...

[rescuema in reply to ladya2020]

It's the same link? Yes, they're doing some research in the area and hopefully people don't risk experimenting on themselves prematurely.

[ladya2020 in reply to rescuema]

Amen to both thoughts.

[Trixiedee in reply to rescuema]

Which magic mushroom thread?

[rescuema in reply to Trixiedee]

here you go

healthunlocked.com/parkinso...?

[MarionP]

MDMA destroys the dopamine producing cells, resulting, sooner or later but definitely can be sooner, depending on the dose) in total paralysis and possibly therefore "locked in" syndrome (somewhat like ALS). Want to see a real life mummy, a good heavy dose of MDMA can make the subject one for life.

[Ajssister in reply to MarionP]

Do you have evidence based research to back your claims?

[MarionP in reply to Ajssister]

"Any?" Surely you jest. And by the way, it's not "my" evidence. Try lifting a finger, do a little homework on your own, you will convince yourself if you are competent to find and consume research.😃 If you're not, it's not my job to "sell" you, having nothing to gain from it. This is a long settled question, though.

[ladya2020]

Just in case there is validity in the brain research I have resolved to add more tryptophon rich food to my diet since tryptophon is said to produce seratonin which increases dopamine production. Easy enough to do since food includes, salmon, poultry, nuts and seeds, oats, greens, bananas, etc.

[MarionP in reply to ladya2020]

You might consider looking into L-tyrosine.

[CaseyInsights in reply to MarionP]

Indeed!

My spouse currently use 500mg of L-Tryptophan in her night stack. Works well - no problems with sleep.

Synthesis: L-Trytopan - 5HTP- Serotoin - Melatoin.

May just include another 500mg for the after breakfast stack.

Looking to see if her daytime tremors improves 🌺✌🏾🌺

[MarionP in reply to CaseyInsights]

When you use an essential amino acid external supplemental dose, that acid competes with, thus may imbalance, the other essential amino acids for absorption. Tyrosine is manufactured by your brain from the essential amino acid phenylananine, without interfering with amino acids. Tyrosine is converted directly into dopamine behind the blood brain barrier.

[CaseyInsights in reply to MarionP]

Don’t quite understand the point being made here.

I do understand the ‘amino acid competition’ part, but this is all par for the course once you begin dopamine supplementation. Not so !

Her Dopa stack contains L-Tyrosine and L-Dopa. Works just fine 🌺

[MarionP in reply to CaseyInsights]

I'm sure it does if you have tyrosine and ldopa and phenylalanine. Oral dopamine won't work but the precursors certainly do. Whatever preserves you from needing to use pharmaceutical ldopa, because when it ultimately quits she'll be SOL, so you conserve its need with the subtles that help native production of ldopa for as long as the cells can make it...Cinemet is pure replacement therapy and eventually the pharmaceutical ldopa will produce more side effects than benefit. But I'm sure you might possibly already know that.

[Surfdoc1 in reply to MarionP]

Gotta Jump in, Can someone explain what you all are discussing related to supplements /Aminos that it sounds like you are taking instead of sinemet . specifically the statements about Tyrosine and phenylalanine vs Sinemet

[MarionP in reply to Surfdoc1]

Not "instead." You will first need to learn what dopamine is, what phenylalanine is, what tyrosine is, what sinemet is, and what catecholamines are, what L-dopa is, what five HTP or 5 hydroxy tryptophan is, and how they all relate to Parkinsons. These you must do on your own then we can have a discussion if you still need. Off you go now to do your basic homework.