APOE4: Risk factor for Alzheimer’s disea... - Cure Parkinson's

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APOE4: Risk factor for Alzheimer’s disease breaks the blood–brain barrier.

aspergerian13 profile image
10 Replies

Risk factor for Alzheimer’s disease breaks the blood–brain barrier. APOE4.

People who carry the gene variant APOE4 are at higher-than-average risk of developing Alzheimer’s disease. It emerges that this variant is linked to defects in the blood–brain barrier and subsequent cognitive decline.

nature.com/articles/d41586-...

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aspergerian13
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MarionP profile image
MarionP

Nasty!! Don't let's allow the insurance carriers or fiances to find out.

SilentEchoes profile image
SilentEchoes

It's a risk factor only, without exposure to xenobiotics it is benign. Genes are our tendancy and not our destiny. This is a modifiable risk. It trips my trigger when research is patient blaming.

MarionP profile image
MarionP in reply toSilentEchoes

The risk is "modifiable" how?

MarionP profile image
MarionP in reply toMarionP

Still waiting. The risk in this case is "modifiable" how?

fifthbird profile image
fifthbird

I have two copies of this genetic variant. I'm pretty sure the potential stress caused by knowing I have this and worrying about possible outcomes is worse than their simple existence, since I'm already doing all the recommended things to take care of myself. I'm going to forward this to my MDS and then try not to think about it!

LAJ12345 profile image
LAJ12345 in reply tofifthbird

Good plan it’s only statistics😊

fifthbird profile image
fifthbird in reply toLAJ12345

❤️

MarionP profile image
MarionP in reply tofifthbird

"Good plan?" So you know it's changed by stress? Me, I always feel better after worrying.

fifthbird profile image
fifthbird in reply toMarionP

We might not disagree! When you say you feel better after worrying, it sounds like you worried and then you stopped. That's what I did, too -- after learning about it and taking some steps that felt productive. What I meant is that I don't want to dwell in fear. In my own experience, chronic stress does lead to poor health (not to mention happiness) outcomes.

Other APOE4 news that is relevant and which I'll be researching:

alzforum.org/news/research-...

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