I was talking to someone else with PD and told them I took 100cr every 2+half hours and they told me that it was dangerous to take them so often as the were designed to be take every 4+ hours .
I’m worried now as are regular Sinemet,gives me even less on time
Has anyone heard this
I would like to try rytary which is meant to me a superior slow release but i cant get it in uk only if I lived in USA
Does anyone know how I could get it shipped in
P
Hi Connie18: When you take a dose of regular Sinemet OR Sinemet CR, a portion of the dose is still in your blood when you take the subsequent dose, so with each successive dose, you are actually increasing your effective dose in your blood (even if you are ingesting the same amount of pills each time)! With "short" interdose intervals, this effect is compounded/amplified. And further compounded if you take many doses throughout the day... This effect is greater with Sinemet CR than with regular Sinemet, because Sinemet CR stays in the blood longer. As for "danger", you should know when you are becoming over medicated by the accumulation of successive dose by the appearance of dyskinesias (this will tell you the amount of levodopa in your blood is too high)... Anyway, you should discuss this with your doctor...
Well put.
Yes very well put
But I don’t get peak dystonia but wearing off and kicking in type
I appreciate your clear answer but it goes to the wrong person .i, try one,final time
Yp
I am on Rytary. I think that it would not be worth the cost. It’s been an ordeal getting to the proper dose and the medication is not that much more effective than Sinemet CR.
See also the recent thread started by johntPM - Approximating the pharmacokinetics of Rytary using four doses of IR C/L:
Agree about the Rytary. My husband was on and it did not provide that much extra "ON" time and it was VERY expensive.
Connie18,
I am 61 female, 7 years since diagnosis. My best meds now, after trying at least 20-25 diff meds.....are
1 ea 25-100 c/l immediate release with 1 ea 25/100 c/l cr at 6am, 9, 12, 3 & 6pm. Seems to work w least amt of off time. Depending on what I eat I may have to take an extra half of the immediate release at noon because sometimes the off time is a little too long around that time maybe because of what I eat. I also take Effexxor xr 37.5mg for fibromyalgia and depression. I have been taking this for 20 years. Best of luck.
I take the same as you 100cr together with 100;immediate release every 2 and half hours but what to you do in the evening and through the night
Intakesbove mix from 8to 6.30 and at 9 i take. 200 cr to go to bed with 2 larazapam and 75 mg pregabalin
I also have the Neupro patch, 2 mg that helps with the evening & nites. I put the patch at 8am every 24 hours. Sorry I left that out. Keep in touch.
I really wish id never taken it through the night as I can’t sleep without it and it makes me get really bad early morning dystonia especially in my face and i wouldn’t have this problem if I hadn’t been. Given it to take at night as I didn’t need it at the time
Connie how long have you actually been taking all the Parkinson's meds? Do you have any dyskinesia? I'm on a low dose of sinamet, half a 100/25 , 2 X day with one scoop of macuna powder, the natural beige coloured powder from Amazon 2 x. per day ....and 2 sinamet 100/25 cr at night . But I may need more and was thinking of taking more sinamet. I'm worried about dyskinesia. How will I know I have it? Please do you have any suggestions.? I'm feeling anxious between meds. Thanks
I'm surprised to hear how often PD meds are taken, even in our group here, and then I see a lot of deskenesis. Is there a direct correlation? My hubby only takes one dose at night. He does get tremors toward the next eve and has trouble with balance, getting up and down, and is sleepy a lot but overall he's doing pretty well. Main problem is double vision in one eye. Surgery to correct it didn't work. It started a few months after he had cataracts removed a few years ago. We both need more activity but are not doing it.
M.A. In U.S A
Mucuna without Sinemet?
Titrating down on Sinemet experience
Underprescribing Sinemet for PD? 
Side effect of Sinemet
sinemet and mucuna pruriens
