REPORT: Completed 35 days of GJ Testing...

[TheLordsWeapon]

Hello, everyone,

After 35 days of GJ testing, I'm now up to 250ml of GJ first thing in the morning and have no more the rest of the day...

My "ON" time after the first dose of the day has gone from 3.5 hours to 5.0 hrs, 2nd dose of the day has gone from 3.5hrs to 4.5hrs, third and fourth doses of the day report the same "ON" time increases, about 3.5 to 4.5 hrs.

NOTE: After the first week of testing, I increased the GJ from 100ml to 250ml each morning and decreased the C/L from 250mg four times a day down to 200mg four times a day and lost all "ON" time increases reported above.

Just going to keep drinking the GJ and thank God and Wriga for the substantial "ON" time increases I have experienced.

Praise the Lord Jesus Christ!!!!!

God Speed

[wriga]

I have to say it, "Praise the Lord".

But don't praise me, I'm just happy to have stumbled on what I can now call "The levodopa half-life anomaly". It was not rocket science to resolve it and should have been done 30 years ago.

Thanks for sharing your results.

[wriga]

Hi again,

Have you noticed any qualitative changes in other symptoms : dyskinesia, dystonia, energy levels, dreams, sleep, pain etc. ?

You seem to be on a very high total dose of levodopa, 4 x 250 = 1000 mg/ day and you reported loss of on-time when you cut to 4 x 200 after the first week on 100 mg of GJ.

You probably were too optimistic and acted too soon in the process. GJ inhibition of CYP3A4 in the liver is a process, it takes time to stabilise and it is not linear.

Now that you are stabilised on 250 ml GJ, I suggest that you try again to reduce the levodopa dose.

Best regards,

Albert

[Despe in reply to wriga]

Albert, I emailed one of my husband's doctors all the information and research you have done. If she responds, I will let you know.

[wriga in reply to Despe]

Wow, you were quick off the mark Despe. Let's hope you get a reaction.

Thanks for your continued commitment.

Albert.

[Despe in reply to wriga]

I thank you for your scientific research, we owe you a lot! I am and will be doing anything that will help all PwP.

I hope that she will respond.

[pdpatient in reply to wriga]

Response, not Reaction right?

[TheLordsWeapon in reply to Despe]

Good move!!!

[Despe in reply to TheLordsWeapon]

Thanks, hope it pays off.

[Not4evr in reply to Despe]

Could you please update on your husband's use of GJ.

[Despe in reply to Not4evr]

Sure. He is still drinking GJ, 4 hours away from his thyroid meds. Our pharmacist recommended NO GJ at all. I have read though that if you ingest it at least 4 hours away from your thyroid meds, there is no problem.

[TheLordsWeapon in reply to wriga]

Thank you Albert for the advice on c/l dose adjustment, thats extactly what i planned on doing starting tomorrow

God Speed!

[Xenos]

If I dare ask, what is Gj ?

[Enidah in reply to Xenos]

I think it’s grapefruit juice

[ruff1 in reply to Enidah]

Yes it is !

[Ep0522]

Wish I could try it, but cannot due to.reaction with metoprolol, the only other prescription I take .

[TheLordsWeapon]

If i recall thats a BP med,,, ive been taking Propanolol for BP for 5 years, have no probs with that interaction, talk to your doc about maybe switching to different med...

[JAS9]

Thanks for posting, Weapon. I appreciate the update. I've been drinking 100ml of GJ a day for 11 days. I've noticed no changes other than maybe sleeping longer. I might go up to 200 in a few days.

[TheLordsWeapon in reply to JAS9]

God Speed Jas! 8)

[Not4evr in reply to JAS9]

Could you please update on your experience with grapefruit juice.

[maryalice]

I would like to read your research o G J. Where can I find it? Thanks.

[maryalice in reply to maryalice]

I will message it to you.

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