Anticholingeric Meds via PD lead to risk of dementia

[sharoncrayn]

Interesting (observational) study headlined by Yahoo and USA Today ... today (June 25, 2019) citing a study of out of the UK (U of Nottingham) finding a link between dementia (and probably its various varieties) and some anticholingeric drugs sometimes prescribed by physicians for certain types of PD patients. Basically these drugs are neurotransmitter blockers, which may or may not be a good thing depending on the individual's "rigidity" and its severity. They obviously can help some PD patients suffering from this situation.

I'm not a physician nor a neurologist, but my guesstimate here is that PD eventually leads in many cases to neurotransmitter damage regardless of almost anything some PD patients and their physicians can do. Is this situation (dementia risk) a "flip of the coin" for some PD individuals?

Probably. It is the standard trade off we find all the time, at least most of the time.

Since some of these AC drugs are more risky than others, check with your physician if you are taking one that he/she is prescribing one that presents the lesser risk.

[lempa_nik]

Here's the original article

jamanetwork.com/journals/ja...

Here's a discussion of the foregoing:

beingpatient.com/anticholin...

[Despe]

Sharoncrayn,

Your writing style doesn't indicate a PwP, are you?

[sharoncrayn in reply to Despe]

see my profile

[Despe in reply to sharoncrayn]

Did, thanks. Impressive.

[Kia17]

Hi Sharon

Thank you for your posts.

Is there any correlation between secondary dystonia and methylation?

Can SAMe interfere with the Cholinergic or anticholinergic agents either in CNS or PNS?

Thank you

[sharoncrayn in reply to Kia17]

Kia:

Does a correlation exist? I don't think so because secondary dystonia is highly correlated to the environment, not to internal methylation (which I assume you are referring to). Personally, I think one could make a decent case that PD is in some respects ( or primarily) a form of dystonia, or at least the symptoms.

Which begs for the question to be asked...is dystonia (or secondary dystonia) in some form the forerunner of most PD?

IOW: something outside the brain is causing the brain to lose its dopaminegeric cells. The PD disease is simply a reflection of the individual's susceptibility to the environmental toxins. Hence, the drugs lose their effectiveness over time if the person remains in their environment. And it becomes progressive.

This is my opinion. NO citations for the citation crowd.

S

[Kia17 in reply to sharoncrayn]

Thank you Sharon

[sharoncrayn in reply to Kia17]

My answer was somewhat short sighted.

If you change your question to "DNA methylation"........?

I would say (in theory) yes. A correlation probably exists because we know that some of your DNA exists in your mitochondria. DNA methylation is simply (not so simply) a modification process that modulates your gene expression. It maintains (or tries to do so) your DNA's integrity and stability among other things.

Cancer tumors often show aberrant methylation. Aberrant DNA methylation can deactivate about half of your tumor-suppressor genes.

I would assume our environmental toxins can create ADM.

[Kia17]

Sharon

I was referring to enzymatic methylation if has anything to do with Cholinergic system. In another word can SAMe become a methyl doner in the process of acetylcholine production.

Thanks

[sharoncrayn in reply to Kia17]

You are over simplifying things. IMO, way too much.

It isn't all that simple. methylation starts with multiple interrelationships across several chemical processes and substances, first and foremost which is DNA methylation. Simplistically, as an extreme example, if you don't have any choline, methionine (via SAM), B-6 and B-12 in your system, and many people don't, it won't matter what you do. It Isn't going to matter very much if at all. Popping a tablet will not resolve the lack of the necessary elements.

METHYL SOURCES ARE INTERRELATED.

This is the way I see it. I am sure someone else would disagree.

S