MSA: Spread of pathological α-synuclein from urogenital nerves initiates multiple 2 system atrophy-like symptoms

[aspergerian]

Spread of pathological α-synuclein from urogenital nerves initiates multiple

2 system atrophy-like symptoms.

2019.

529594.full.pdf.

Abstract

.

36 Multiple system atrophy (MSA) is a fatal adult-onset movement disorder with autonomic failures,

37 especially urogenital dysfunction.

The neuropathological feature of MSA is the accumulation of

38 misfolded α-synuclein (α-Syn) in the nervous system. Here, we show that misfolded α-Syn exist

39 in nerve terminals in detrusor (DET) and external urethral sphincter (EUS) of patients with MSA.

Moreover, α-Syn preformed fibrils inoculated into the EUS or DET in TgM83 40 +/- mice initiated the

41 transmission of misfolded α-Syn from the lower urinary tract to brain, and these mice developed

42 α-Syn inclusion pathology through micturition reflex pathways along with urinary dysfunction and

43 motor impairments.

These findings indicate that spreading of misfolded α-Syn from the autonomic

44 control of the lower urinary tract to the brain via micturition reflex pathways induces autonomic

45 failure and motor impairments. These results provide important new insights into the pathogenesis

46 of MSA as well as highlight potential targets for early detection and therapeutics.

[Hidden]

I would really like to know what that posting is supposed to be telling us about MSA. It’s all way above my head! Anyone out there that can translate for me?

[WC309 in reply to Hidden]

“These findings indicate that spreading of misfolded α-Syn from the autonomic control of the lower urinary tract to the brain via micturition reflex pathways induces autonomic failure and motor impairments”

This seems to say.......an abnormality in your lower urinary tract apparently migrates up a nerve to the brain where it creates a fatal form of atypical Parkinsons

[Hidden in reply to WC309]

Would you consider this useful and practical information or just a piece of preventative knowledge?

Forgive méforme bing so dim ..... It still doesn’t tell me much but I am interested as I have recently been told that I probably have MSA as well as PD. 75 yr old female in Canada.

[Rhyothemis in reply to Hidden]

It is interesting in terms of understanding how the disease begins. It doesn't really provide any practical information regarding either treatment or prevention - though future studies may have implications for prevention. It may also have implications for diagnostic testing (perhaps a urine test could be developed, if MSA patients shed misfolded alpha-synuclein in their urine).