Proof that fatigue is part of Parkinson's etiology.

[parkie13]

us5.campaign-archive.com/?e...

We are missing gray matter but getting fatigue in return.

[park_bear]

Interesting. A good first step. Now if we only knew what to do about it. Actual study at this link:

sciencedirect.com/science/a...

[parkie13 in reply to park_bear]

Now we can say that we have the proof. We're not making it all up. It's all really scary.

[LAJ12345]

I know I am becoming repetitive but I trialed my husband who has Pd on the Hardy’s product as he was extremely unwell at the end of last year and within 3 days he was feeling 10 times better and now 6 weeks later he has lots of energy , no anxiety or fatigue and is busy doing jobs around the house that he hasn’t been able to for years. It is reasonably expensive but it replaced a lot of other supplements he was taking so when you look at the list of ingredients it has and the difference it makes it is well worth it.

hardynutritionals.com/produ...

I am fairly sure chemical imbalance was the root of his fatigue and apathy since this worked so quickly and I am interested finding out if it is as effective for others as it was for him. I keep posting about it as I know not everyone gets every post.

I am beginning to think his version of Parkinson’s is just one version of dietary deficiencies, like b1, but maybe other micronutrients are also deficient. If you have tried b1 and stopped improving maybe try this in case it is another nutrient limiting progress.

[parkie13 in reply to LAJ12345]

Hi, what products is he on right now? What do you think made a big difference in his fatigue? Thank you Mary

[LAJ12345 in reply to parkie13]

Hi Mary, take a look at my profile as I have listed all the things he is on and believe me we have tried everything natural in the last year!

The biggest turn around came when he started on the Hardy’s daily essential nutrients, and he had been taking their greens and probiotics and inositol for a week or so at that point too. I have become a bit of a fanatic about it in much the same way as others are for b1, mannitol, and fast walking! I would say it is well worth a go but make sure you read the ingredients and if you are also taking some of the individual components separately especially the minerals stop those while you take the Hardy’s. He does take extra thiamine b2, and b3 niagen as well. Extra water soluble vitamins are generally ok but not more minerals. He also had been taking Restore Gold for a month when he started Hardy’s but the change in 3 days of starting the Hardy’s was too dramatic to be due to other things that he had been taking for a month or more. If it was the restore gold I wouldn’t expect such a sudden improvement, but it may be synergy between all the things he is taking.

[Beanie57 in reply to LAJ12345]

Is your husband taking Sinemet or similar... if so is there an issue with taking Harry’s as there is B6 in there. Also is he taking a recommended dose of 12tablets daily.... this is a lot of tablets

[LAJ12345 in reply to Beanie57]

Yes but he only takes 1 tablet first thing of sinemet. We have found sinemet is best taken away from anything else or he gets the judders. He doesn’t think the sinemet does much for him any way so he has avoided taking the 2 x 3 times per day that he has been prescribed. It is the generic form of sinemet not the branded one. From my reading it seems it is very important to take the extra b6 as the carbidopa in sinemet uses up all your b6 which is needed for many of enzymes processes.

Hardy’s have been selling this product for around 15 years or so, and people have been on it for that long without problems. My friends son is 13 and has been on it from about 7 and he is really well now. apparently it is the most studied multi in the world, so they say.

And yes, my husband and my friend’s child are both taking the 12 per day. I was dubious when she told me about it years ago but her son has has done really well on it compared to how he was.

If you look at the ingredients in it there are a lot of things in it, not just vitamins, and the other things make up a lot of the bulk. For example there is alpha Lipoic acid, and they tell me there is 40 mg per capsule so 480mg per day. There is also nac, grape seed, green tea, etc all of which are things that are supposed to benefit PD.

[Beanie57 in reply to LAJ12345]

Thanks for that. Just to clarify does he get the judders if he takes Sinemet with any other tablet ie Thiamine (HDT) or just the Harry’s supplement and how long before taking the supplement after taking the Sinemet do you find is best. We are still trying to find my sisters ideal dose for HDT at present.

[LAJ12345 in reply to Beanie57]

If he has it with breakfast so he takes it with a cup of tea before he gets up then has breakfast about half an hour later. He has been taking it with a uridine tablet for a while and I think that helps but equally it could just be not taking it with food or vitamins. He definitely had quite a violent reaction one day too when he had it with b6 before he was taking the Hardy’s.

Paper on uridine

ncbi.nlm.nih.gov/pubmed/259...

[parkie13 in reply to LAJ12345]

Thank you for writing. I'll probably get some Hardee's but it's going to be in couple months since I want to finish what I am on now. Thanks again Mary

[LAJ12345 in reply to parkie13]

Yes that’s what I thought at first but then I thought I might as well try the Hardy’s first then go back to the others if it makes no difference. And if it does make a difference then I want that difference sooner rather than later! Needless to say we won’t be going back to the other products again so I do have a lot of half bottles left which I am not sure what to do with😂. But they weren’t working him him anyway so maybe they weren’t what they said they were or were degraded or something.

[Icequeen10 in reply to LAJ12345]

Thanks for posting this resource!

[Millbrook]

Did Vitamin B1 help with the fatigue?

[ddmagee1]

There are times when I need to take a nap, for about an hour or so, in the afternoons, because I feel so fatigued and drained. I always feel much better when I get up, and can get my regular chores done. If I miss having a nap, I really feel like my brain needs some R&R and it's difficult to concentrate on doing things. I drag around and fight to stay awake. Several of my family members don't understand why I need a nap. They say I'll sleep better at night if I don't have a nap. I have to get up for a bathroom break at night anyway, and sometimes, peripheral neuropathy is bothering me and I can't sleep well. I do what I have to do, even if some don't understand! Living with progressing PD is not pleasant, and requires adjustments by patients, and their families. What's tough for me, is that some in my family are expecting me to be the same as always, and don't want to make allowances for some of the difficulties I am having. Perhaps it is a lack of understanding, or compassion. That's another reason why I enjoy health unlocked.com. Other people with PD do understand what I'm going through, and that makes life a little easier.

[Butterflygirles]

My general fatigue problem used to overcome me like I’d been hit by a truck. But it’s not as bad now. I still have to rest/sleep especially the day after a really busy day. I can count on it so I try to pace myself that way. I’m wondering if the B1 is the big fatigue helper for me. Also rhodiola helps too. Still trying to live with this “beast”. Happy when I have a good day. Makes me think of the saying “It’s a good day for a good day!”

[sharoncrayn]

Proof of what?

Since the average age of this very small study was 67, (and no measure of fitness was taken),

it is difficult for me to understand how the research team could conclude that the fatigue was not age and/or fitness related as well.

Further, they apparently did not quantitatively measure fatigue across both cohorts,

at least from what I read.

Brain differences between the cohorts was noted, but so what? Is this difference something new?

[parkie13 in reply to sharoncrayn]

It was not known before nobody measured it. Less of gray matter for Parkinson's people.

[sharoncrayn]

I highly doubt that this was the very first MRI study of the PD brain, but possible. By the way, the "fatigue severity scale" measure was identical for both cohorts. What does that tell you? It should tell you something. Does it?

[parkie13]

I just reread the article. We both must have gotten something different out of it. There's definite changes in Parkinson's brain from controls.

[sharoncrayn in reply to parkie13]

As someone with a BS in chemisty and a Ph.d in bio-chem we definitely did get something different out of it.

You are missing my point. PD is NOT an independent variable for elderly fatigue! Some PD patients have it; others don't.

As to brain changes, we have known that for years about PD; it is a neurodegenraive disease for a reason which is an old, old, old story.

It was a poorly designed MRI study which did not control for other relevant variables.

[aspergerian13]

See:

Hypoperfusion : Leukoaraiosis: A Hidden Cause Of Brain Aging - page 1 | Life Extension.

lifeextension.com/Magazine/...

[LAJ12345 in reply to aspergerian13]

Very interesting. Effects sound like PD symptoms.

[aspergerian13]

Also: I have severe postprandial hypotension.