Ensure plus - too much protein ?

[aspergerian]

I have been drinking 3 to 5 Ensuring plus per day. I seem stuffed. Is Eplus interfering with Levodopa \ dopamine and motor function?

[jeffreyn]

Isn't one small tetrapack of Ensure Plus equivalent to one meal? Five per day seems quite a lot.

[aspergerian in reply to jeffreyn]

I agree and wonder how long Ensure's milk protein oiners in the stomach and small intestine.

[aspergerian]

Effect of Levodopa on Orthostatic and Postprandial Hypotension in Elderly Parkinsonian Patients | The Journals of Gerontology: Series A.

academic.oup.com/biomedgero...

When higher-dose therapy is indicated in elderly patients, careful orthostatic and postprandial BP monitoring may be advisable because hypotensive side effects may then become more pronounced.

scholar.google.com/scholar?...

OH and PPH can cause dizziness, lightheadedness, weakness, blurred vision, falls, or loss of consciousness (2). OH is found in 11% to 25% and PPH in 40% to 54% of parkinsonian patients (4)(5)(6)(7).

Antiparkinsonian medication can impair autonomic or cardiovascular compensatory mechanisms and thereby aggravate orthostatic and postprandial BP decreases (3)(6)(8)(9).

Postprandial hypotension.

Review article.

Luciano GL, et al. Am J Med. 2010.

ncbi.nlm.nih.gov/m/pubmed/2...

Postprandial hypotension is both common in geriatric patients and an important but under-recognized cause of syncope. Other populations at risk include those with Parkinson disease and autonomic failure. The mechanism is not clearly understood, but appears to be secondary to a blunted sympathetic response to a meal.

Diagnosis can be made based on ambulatory blood pressure monitoring and patient symptoms. Lifestyle modifications such as increased water intake before eating or substituting 6 smaller meals daily for 3 larger meals may be effective treatment options.

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Postprandial hypotension, defined as a decrease in systolic blood pressure of 20 mm Hg or more, may result in syncope, falls, dizziness, weakness, angina pectoris, and stroke. Postprandial hypotension is distinct from and probably more common than orthostatic hypotension.

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scholar.google.com/scholar?...

On the other hand, the heart rate variation evoked by deep breathing as well as the blood pressure response and the heart rate response to sustained isometric exercise were significantly diminished in the patients with idiopathic Parkinson's disease. These findings indicate a central disturbance of cardiovascular reflex control, whereas the corresponding peripheral pathways seem to be normal.

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Postprandial Hypotension in Clinical Geriatric Patients and Healthy Elderly: Prevalence Related to Patient Selection and Diagnostic Criteria !!!

ncbi.nlm.nih.gov/pmc/articl...

Measuring blood pressure at least every 10 minutes for 60 minutes after breakfast will adequately diagnose PPH, defined as >20 mmHg systolic fall, in most patients. However with definition of PPH as >30 mmHg systolic fall, measuring blood pressure every 10 minutes will miss PPH in one of three patients. With the latter definition of PPH the presence of postprandial complaints is not associated with the existence of PPH

[Parkit]

YES- for sure. Protein will attach to the dopamine & prevent the dopamine action, depending on the dose & timing. Separate the dopamine & protein by 3 to 4 hrs to decrease the interaction of the 2 products

Also, if you forget & take a double dose of dopamine

Drink a bottle of Ensure to decrease the interaction

I have PD confirmed in 2015 (72 yrs)