questions & answers Costantini

Many here are contacting the Doc. Please share your questions and his answers.

[munchybunch]

I write t him and he said it’s important to take magnesium citrate along with the b1. Apparently that helps the absorption.

[Hidden in reply to munchybunch]

Dap1948 "A Parkinson's nutritionist recommended magnesium MALATE to me. There are different sorts of magnesium..... Beware however, too much magnesium can increase the symptoms you want to reduce, but you should be safe if you stick to the recommended dose. .... the recommended dose which is about 400mg.."

[Kia17 in reply to Hidden]

Thanks Roy. I noticed from your profile that you are taking 1250 mg Magnesium Malate but in this post recommends 400mg from a nutritionist. Please can you elaborate.

[Hidden in reply to Kia17]

on the bottle, recommends 1 - 3, 425mg tablets a day with meals

[Kia17 in reply to Hidden]

How much do you take?

[Hidden in reply to Kia17]

1 - 425mg tablet a day, w/o food

[Kia17 in reply to Hidden]

I think the reason for your tremors is that amount of Magnesium.

Dr Costantini recommendations to me was 300 mg Aximagnesio . It consists of :

magnesium malate, magnesium succinate, magnesium chloride, magnesium sucrosomial® – Ultramag® (magnesium oxide,pyridoxine hydrochloride (vitamin B6).

IMHO; Contact him and ask if you need to adjust the magnesium. Tell him if he recommends Aximagnesio

pegaso.eu/en/store/nutritio...

[Hidden in reply to Kia17]

I'll stop magnesium and see what happens.

"Our take on magnesium is that there is no direct link to PD.

Small changes in magnesium in the blood (0.1 for example) ca result in worsening of any neurological symptoms in any neurological disease. Reflexes, altertness etc. can all change and worsen with high and low Magnesium levels."

forum.parkinson.org/topic/9...

[Kia17 in reply to Hidden]

We need magnesium for production of Dopamine and for many other biochemical reactions in our body.

I think before stopping send him an email and ask then based on his recommendations adjust your dosage

[Hidden in reply to Kia17]

Do you know if there is a United States version of this ?

[Hidden in reply to Kia17]

Last nite I cut back my magnesium to 100mg and this morning I have joint pain

[kaleiann in reply to Kia17]

is it possible to order in us?

[keepsie in reply to Hidden]

What is the serving size? If it's more than 1 tablet then you are taking too much.

[Hidden in reply to Kia17]

Vitacost Magnesium Ultra -- 300 mg - 180 Capsules from Amazon

magnesium is 300 mg once to twice daily

"Magnesium malate: pain relief

Malic acid, bound to magnesium to form magnesium malate, is an intermediary in the Krebs cycle and involved in energy metabolism. Dr Gee Abraham first hypothesised that fibromyalgia syndrome may be due to a defect in cellular metabolism characterised by low ATP production (leading to the characteristic symptoms of fatigue) and a build up of organic acids (explaining the diffuse muscle pain). Supplementation with magnesium malate – to provide magnesium for acetyl-CoA synthesis and malic acid for malate dehydrogenase activity – may be able to improve energy metabolism and relieve fibromyalgia, he theorized.

In an open label study to test this hypothesis Abraham et al (1992) reported that oral treatment with magnesium malate (300-600 mg magnesium and 1200-2400 mg malate daily) for 8 weeks improved fibromyalgia pain (16). A follow up placebo controlled trial however failed to demonstrate benefit but this may be due to a shorter treatment duration (4 weeks) and lower dose (300 mg magnesium and 1200 mg malate daily) (17).

Get a magnesium top up

According to clinical studies a typical dose of magnesium is 300 mg once to twice daily and should be continued for at least 3-4 months to notice benefits. Choosing a particular type of magnesium such as orotate, glycinate or malate may have some added benefits. When selecting a product make sure you place quality first."

timeforwellness.org/blog-vi...

[faridaro in reply to Hidden]

Roy,

I very much appreciate you sharing your protocol so generously with us - lots of good information! I looked up Vitacost Magnesium Ultra ingredients and one of them was a red flag I want you to be aware about - the Magnesium amino acid chelate which can have magnesium bound to glutamate or aspartate - both can be potential neurotoxins, see article drcarolyndean.com/2011/01/g...

You can ask Vitacost about which particular amino acids have been used in " amino acid chelate" of this product? I've done this myself in the past with a different company and got an answer that it was aspartate. That's how they try to cover up glutamate and aspartate content which is undesirable, especially in our condition.

[park_bear in reply to faridaro]

The Magnesium amino acid chelate I have seen is the glycinate, which is what is in the Swanson's version I currently take.

[faridaro in reply to park_bear]

Yes, I looked up Swanson's Magnesium Amino Acid Chelate (which is just the title on the bottle) and in ingredients it states "magnesium glycinate" which is good, but the difference with the Vitacost magnesium is that the Vitacost have "amino acid chelate" listed along with other forms of magnesium in the ingredient section.

[Juliegrace in reply to Hidden]

I was taking magnesium glycinate, then changed to magnesium threonate, but after some info from the user easilly I found a magnesium that I believe is closer to the aximagnesium (sp?) that we can't buy in the US. It can be found a little cheaper than Amazon if you search it. The second link is a picture of the ingredients.

amazon.com/Ayush-Herbs-Supr...

ruved.com/ecom_img/original...

[munchybunch in reply to Hidden]

Thanks for that.

[munchybunch in reply to Hidden]

I’ve tried to get b1 Vitacost but they don’t ship to Australia. Do you know of any other cheaper brands pls? Solgar works out pretty pricy!! Do you live in the Uk?? Thanks

[Hidden in reply to munchybunch]

live in USA

[Boyce3600 in reply to Hidden]

I have been out of touch for a while. How/ where did u / can u find a Parkinson's Nutritionist?

[Hidden in reply to Boyce3600]

ask Dap1948 "A Parkinson's nutritionist recommended

[Boyce3600 in reply to Hidden]

Thx

[Hidden in reply to Boyce3600]

healthunlocked.com/user/dap...

[Erniediaz1018 in reply to Hidden]

Thanks

[dadcor]

Since I started Magnesium L-Threonate together with B1 two weeks ago, I noticed I sleep much better than before... No other improvements ..yet

[999---666]

great site, want to follow. I think your another one that avoided medication to the last minute, and didn't get much results when you obeyed.

how are you feeling now?

i'm thinking of switching to mucana p, cheching out lithium.

[Hidden in reply to 999---666]

Now! Last nite I cut back my magnesium to 100mg and this morning I have joint pain. I am returning to 425mg daily dose. (malate)

[999---666 in reply to Hidden]

check it out, but I think it's conterindicated, it hasto be in proportion with another mineral, the name escapes me for moment. it has to be in correct proportion, or else it depletes the partner mineral..

[Hidden in reply to 999---666]

calcium?

[Dee1980 in reply to 999---666]

Potassium. I've got my dad on Magnesium Malate (citrate isn't recommended on the site I go to as it pushes down ferroxidase function) but any magnesium can lower potassium, so I'm being a bit more careful.

[Hidden in reply to Dee1980]

Included in my regimen is 4 x 99mg potassium twice a day recommended by neuro to prevent leg cramping

[999---666 in reply to Hidden]

Karen carpenter and other anorexics often die from potassium deficiency. your heart requires it's quoto, no maybes about it.

[Hidden]

copy: "hello Roy I was just today from doc Costantini, I asked him if I could remove or diminish levodopa, He said no, because b1 has a restorative effect on the surviving cells that will be forever as long as it is used, but levodopa reduces stress and the chemical work that the few remaining cells (for example, 10.20.30% of the total according to the years of PD passed without b1 ) have to do to produce all the dopamine necessary for the body. He made me notice the fact that if one removes the b1 even for a week or two is not affected, but if one removes the levodopa is affected instantaneously, this precisely because the levodopa serves the few living cells to produce with less chemical effort all the necessary dopamine. The b1 saves cells from death by the disease and makes them survive long and forever stabilizing it. According to him levodopa does not cause dyskinesias and showed me a video of a patient who took care of was quite serious that moved everything from sitting because he took so much levodopa, after a three month b1 was still stiff but walked and without convulsions , this without changing anything in the medicines but only with thiamin. I asked him why there are ups and downs, in the days or in the cold seasons and he told me that it does not depend on a worsening, but on the variable response of the levodopa that is subject both to the diet that changes the reaction of the body to the cold. I hope it will help you even if I think you will not like it, and that is perhaps a repeating things that the doc has already said. But that he saw me in response to my questions.

The good news is that thiamin stabilizes the disease forever."

[Kia17 in reply to Hidden]

Thanks Roy for sharing Dr Costantini’s response.

When I asked him these questions in person , he answered the same as did to you. Though,I didn’t ask about up and down days but it has always been a question to me.

[Greenday in reply to Hidden]

If Thiamine was able to degrade misfolded α-synuclein via autophagy and rescue Dopamine neurons, that would lead to the increase of Dopamine levels in the brain and the need for less amount of levodopa- induced dopamine. It is the rescue agent, that leads to the reduction of oxidative stress and the protection of Dopamine neurons not the levodopa itself. That said, the more the dopamine neurons rescued the less the need for levodopa-induced dopamine, as more dopamine is naturally released in the brain. However this does not seem to happen with B1 Thiamine and the same or more amount of levodopa is needed for the effective treatment of symptoms, which negates the purpose of Thiamine as effective rescue agent of the dopamine release neurons. Therefore, I suggest another mechanism might exist than the one suggested.

My guess is that, through some mechanism, thiamine may be involved in upregulating/downregulating Dopamine receptors (DA). Thiamine may upregulate Postsynaptic receptors (receiving dopamine) and downregulate Presynaptic receptors (releasing dopamine). The ratio Post/Pre possibly favors the Postsynaptic receptors. In the presence of increased Postsynaptic receptors, levodopa-induce dopamine may cause less dyskinesia as it finds affinity to more receptors. In the presence of downregulated Presynaptic receptors and upregulated Postsynaptic receptors equal or more levodopa is needed to produce a greater relief of symptoms.