everything you ever wanted to know - by F... - Cure Parkinson's
everything you ever wanted to know - by Frank Church
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MBAnderson
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The essay and PPT fail to mention the locus coeruleus (ceruleus) and the nucleus basalis. The historical focus on the substantia nigra has become outmoded as a ruling model, though the SN is still important, as are treatments for motor symptoms, also the newer model needs include other neurotransmitters, their affected nuclei, and related non-motor symptoms.
Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases.
Great article, thanks.
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