Twins with Parkinson's

[MGP201]

Do you know twins with Parkinson's disease?

[Hikoi]

siblings but not twins

[PDConscience]

Out of curiosity I found the following:

"Scientists have long known that genes alone cannot explain why some people get Parkinson’s and others don’t. While a handful of genetic mutations are linked to the disease, about 90 percent of cases of Parkinson’s are “sporadic,” meaning the disease does not run in the family. And twins, even identical twins, don’t usually get Parkinson’s in tandem. In one of the largest longitudinal twin studies of the disease, Swedish scientists reported in 2011 that of 542 pairs in which at least one twin had Parkinson’s, the majority were “discordant,” meaning that the second twin was unaffected. The discordance rate was higher for fraternal twins, who are no more alike genetically than any two siblings. But even identical twins had a discordance rate of 89 percent.

"So if genes don’t explain most cases, how about the environment?"

Source: geneticliteracyproject.org/...

[Hikoi in reply to PDConscience]

This is an area we are currently seeing rapid advances asnd revised thinking .eg:

Parkinson's disease (PD) was previously described as the prototypical sporadic disease; however, rapid advances in population and molecular genetics have revealed the existence of a significant number genetic risk factors, prompting its redefinition as a primarily genetic disorder.

academic.oup.com/bmb/articl...