First paragraph in Shoji et al 2014 presents distinctions among PD's
major subtypes and and subtypes within the major groupings. The
study's first paragraph is here presented by separating some of the
sentences
Neural substrates of cognitive subtypes in Parkinson's disease: a
3-year longitudinal study.
Shoji Y, Nishio Y, et al; PLoS
One 2014 Oct 20;9(10):e110547.
ncbi.nlm.nih.gov/pmc/articl...
The cognitive features of Parkinson's disease (PD) are heterogeneous
and can be categorized into several major subtypes.... However, the
neural substrates underlying the cognitive subtypes remain to be
elucidated. Recent studies have demonstrated that there are
correlations between cognitive impairment and non-cognitive features
in PD: patients who develop dementia have a higher age of onset,
rapid symptomatic progression, anosmia and a non-tremor-dominant
motor subtype....
Consistent with these observations, neuropathological studies have
suggested that the anatomical distribution of Lewy-related pathology
differs depending on the clinical subtypes. The pathology rapidly
evolves from the brainstem into the cerebral cortex in patients with
the non-tremor-dominant motor subtype and/or dementia, whereas it is
relatively confined to the brainstem for a longer period of time in
patients with a tremor-dominant motor subtype and no cognitive
impairment....
If such provisional clinico-pathological relationships are genuine
and if specific subtypes of cognitive impairment are associated with
the future development of dementia, these cognitive subtypes may be
associated with specific clinico-pathological subtypes.
.