Hello, Lately Parkinson has been winning on me ! My Doctor today prescribed Rasagaline, I am undecided if I should add it to Sinemete or my other option she said is increase Sinemet.
Any of you take it? any side effects? About the combination with Sinemet? any comments?
Thank you
chantal
1mg rasagiline gives total symptomatic relief roughly equivalent to about 100mg levodopa (taken with carbidopa). The nice thing about it is that it has an almost level effect over a whole day, whereas levodopa only lasts for about 3 hours. The bad news is that since its benefit is spread across the whole day, its impact at any moment is low. (100mg levodopa over 3 hours = 33mg/hr; 1mg rasagiline over 24 hours = 100/24 = 4mg/hr levodopa equivalent.) For most people the dose is 1mg/day; taking more gives no advantage.
Rasagiline possibly slows down the rate of progression of the disease. There has been much controversy amongst researchers and regulators as to whether this is the case. The latest research suggests that rasagiline may slow progression by 20%.
John
i have rasagiline 1 mg for about 7 years together with stalevo and neuropatch 4 mg. no side afects
I have been on Rasagiline along with Mirapex for about 2 years( since diagnosed). I am donig well with the combo. No noticeable side effects thus far.
Be very careful. I am on Sinemet, and last year my Neurologist prescribed Rasagiline to complement my Sinemet. The complement soon became an insult. I went into a downward spiral into depression, which eventually led to my attempt to end my life. I have been off of the Rasagiline since October, and life looks a whole lot different now. I can't recall who said this the other day, but I think it is very wise advice; "My advice is to make changes ever so carefully, titrating up or down cautiously. Have very low expectations, and monitor changes closely, caring not to infer quickly any correlation. Managing symptoms and consequences is an art form requiring a very large dose of patients. There is no cure, or panacea for that matter." Be well and take charge of your own health care.
I was on a sinemet only regime and my neurologist was increasing the dosage every time I went to see them producing some bad side effects. I am now on a medication regime that involves a cocktail of drugs and I'm the best I have ever been. My idea is to try anything that's offered to me and if it doesn't work then try something else also to research to find out if there are any more drugs that might help me and have a discussion about them with my neurologist the next time I see them. Everyone is different.
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