Contagious ?

diseases such as Parkinson's and dementia can be contagious, according to researchers at the Human Microbiology Institute, who have published research linking the diseases to newly discovered bacterial viruses.

bioportfolio.com/news/artic...

[GailBailey]

It does sound unbelievable, I might even say rediculous. I have PD and in the 6 years plus that I have been diagnosed, I have met many people with this condition and they like me don't know anyone in their respective families that have it.

[beauxreflets in reply to GailBailey]

I actually think it is very likely that the 'leaky gut' syndrome is part and parcel of PD,

Continual catching a bug or two when the immune system is on very low ebbs due to stress, and or alongside something like 'chicken pox' or returning shingles, etc

[park_bear in reply to GailBailey]

Yes, it is unbelievable because the "Bioportfolio" article is a false and indeed ridiculous interpretation of this research: ncbi.nlm.nih.gov/pmc/articl..., which merely says that the effect of some bacteriophage on intestinal flora can result in leaky gut syndrome in rats. That's interesting, but it is also true that bacteriophage have been used safely in humans for over 100 years to eradicate infections. Be that as it may, the researchers never said or implied anything to justify Bioportfolio's clickbait headline.

[haugenk]

This was indeed some News. Thank u very much for this very interesting link. Hard to believe we might see any benefits from it, bur generations to Come may look at a brighter Future.

[beauxreflets]

Very interesting; lets hope a treatment for a 'leaky gut' is forthcoming along with medications to knock the wee bacterial viruses on the head. I wonder whether something like 'milk of magnesia' will do the first part?

[BillDavid]

/ng results for bacteriophage

Search instead for bactoriophage

Search Results

Bacteriophage - Wikipedia, the free encyclopedia

en.wikipedia.org/wiki/Bacte...

Wikipedia

A bacteriophage /ˈbækˈtɪər.i.oʊˌfeɪdʒ/ (informally, phage /ˈfeɪdʒ/) is a virus that infects and replicates within a bacterium. The term is derived from "bacteria" and the Greek: φαγεῖν (phagein), "to devour".

‎Phage therapy · ‎Lambda phage · ‎Enterobacteria phage T4 · ‎Bacteriophage T12

bacteriophage | virus | Britannica.com

britannica.com/.../bacterio...

Encyclopædia Britannica

Jun 1, 2015 - Bacteriophage, also called phage or bacterial virus , any of a group of viruses that infect bacteria. Bacteriophages were discovered independently by Frederick W. Twort in Great Britain (1915) and Félix d'Hérelle in France (1917).

Bacteriophage | Phages

phages.org/bacteriophage/

Jul 16, 2013 - Bacteriophages, also known as phages, are viruses that infect bacteria. These phages also require a bacterial host in order to replicate ...

Bacteriophage - Online Textbook of Bacteriology

textbookofbacteriology.net/pha...

Todar's Online Textbook of Bacteriology

Probably every known bacterium is subject to infection by one or more viruses or "bacteriophages" as they are known ("phage" for short, from Gr. "phagein" ...

Bacteriophage Therapy - NCBI - National Institutes of Health

ncbi.nlm.nih.gov/...

National Center for Biotechnology Information

by A Sulakvelidze - ‎2001 - ‎Cited by 908 - ‎Related articles

Bacteriophages or phages are bacterial viruses that invade bacterial cells and, in the case of lytic phages, disrupt bacterial metabolism and cause the bacterium ...

Bacteriophages - Phage-Therapy.org

phage-therapy.org/writings/...

Specifically, bacteriophages are the viruses of bacteria, that is, they are sequences of genes (genomes) which move around from bacterium to bacterium while ...

Bacteriophage therapy: an alternative to antibiotics? An interview ...

news-medical.net/.../Bacter......

Rating: 4.5 - ‎6 votes

Dec 2, 2015 - What is a bacteriophage and how many different types of phage exist? A phage is a virus that ... Bacteriophage viruses infecting bacterial cells.

Who Discovered Bacteriophage? - Microbiology and Molecular ...

mmbr.asm.org/.../793.full....

Microbiology and Molecular Biology Reviews

by DH Duckworth - ‎1976 - ‎Cited by 151 - ‎Related articles

surrounding the discovery of bacteriophage and, I hope, to clear the name of Felix d'Herelle from the aspersions that have been cast upon it. (This paper is part ...

Ties to the resarch suggesting sthet PO originates in the lower gut. Bacteriaphages would be the agents. Contagiuous in the sense would invpolve the transfer of the bacteria within

the fecal material.

BillDavid

[soup]

Bacterial viruses? The article is full of phrases that show the author, not the scientists, was working beyond their understanding. Quotes from the scientists contained qualifiers such as, "possibly, could be" etc.

Somebody has taken thought about a possible mechanism and stretched it beyond belief to write a sensationalist article.

[Janice557799]

understanding this concept, the article doesn't really explain HOW it is contagious, or did I miss that ... reading it again, in a few. If this relates to leaky gut syndrome, how do we attack this problem? would eating a diet that is all alkaline be best? It would seem so as inflammation causes so many problems throughout the body. Inflammation destabilizes cholesterol in our veins causing heart problems. I believe in eating a diet based on bible guidelines, no pork, lots of veggies, lean meats, never any shell fish, so far, so good.

[haugenk]

In such cases, one should always go directly to the root. The actual paper is available for free (open access); why not read it at: gutpathogens.biomedcentral....

[TheresaCurley]

I find this very hard to believe.

[silvestrov]

In order to properly understand this article it must be read in the original form. The summarized article posted is more difficult to understand. Here is the original article:

Bacteriophage infections of microbiota can lead to leaky gut in an experimental rodent model

ncbi.nlm.nih.gov/pmc/articl...

In the Results/Discussion part of the article the authors state that foreign bacteriophages, bacteriophages not native to a human host, can be acquired through environmental contact and thus affect human health. Hence the idea that they can cause contagion. Additionally, this is not the first time someone has suggested that PD may be a contagious disease:

Parkinsons - Just another Infectious Disease?

"Anatomic staging of PD progression suggests that an unidentified neurotropic pathogen in the intestinal lumen triggers abnormal synuclein aggregation that, in turn, initiates a ‘‘prion-like’’ process in the enteric nervous system (ENS) eventually achieving access to the central nervous system (CNS) via the vagus nerve (cranial nerve X) [2-7]. This protein aggregation, manifest as Lewy bodies, targets and destroys dopamine producing cells resulting in both the classic motor and non-motor symptoms of PD [7,8]; with the non-motor symptoms predating the motor symptoms by years, or even decades [9]."

researchgate.net/publicatio...

This sort of phage research may have already been done because though we, America and western Europe, stopped investigating the use of phages in the 20th century, while the eastern block countries, particularly Russia, has continued to experiment with bacteriophages in human health to this day. The phages used in this study were purchased from Russia.

Really the idea that bacteriophages may contribute to Parkinson's disease is nothing new. The toxins produced by certain bacteria have been shown to be a result of bacteriophage infection. E. Coli and Salmonella produce endotoxins called lipopolysaccharides (LPS) and are a result of phage infection. LPS have been widely used in PD testing to see if a drug or supplement can 'attenuate' the toxicity of LPS in either a cell or animal model. Plus there is a case of a lab assistant who had a thumb cut and she was exposed to 10 mcg of LPS from Salmonella and by the age of 28 she had parkinsonism. She was infected at the age of 22:

Parkinsonism caused by Lipopolysaccharides

of Salmonella Minnesota (a Case Report)

"A laboratory worker aged 22 was accidentally contaminated with 10 microgram Salmonella minnesota lipopolysaccharides (LPS) through an open wound on the left thumb."

endotoxin.gmxhome.de/

A typical LPS Parkinson's disease study:

The lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery.

ncbi.nlm.nih.gov/pubmed/187...

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Also, some PWP have Postural Instability and Gait Disorder (PIGD) and this may be a result of intestinal bacterial imbalance.

Gut Bacteria May Influence Parkinson's Risk, Phenotype

"The study showed that another type of intestinal bacteria ― Enterobacteriaceae ― was linked to the severity of postural instability and gait difficulty (PIGD). These bacteria were significantly more abundant in patients with a PIGD phenotype than in patients with tremor dominant (TD) phenotype."

"The study showed that another type of intestinal bacteria ― Enterobacteriaceae ― was linked to the severity of postural instability and gait difficulty (PIGD). These bacteria were significantly more abundant in patients with a PIGD phenotype than in patients with tremor dominant (TD) phenotype."

medscape.com/viewarticle/84...

Types of Enterobacteriaceae bacteria:

"Large family of Gram-negative bacteria that includes many of the more familiar pathogens, such as Salmonella, Escherichia coli, Yersinia pestis, Klebsiella and Shigella, Proteus, Enterobacter, Serratia, and Citrobacter."

medscape.com/viewarticle/84...

++++++++++++++++++++

This study was the first step and who knows where the investigation will go. Science is slow and it takes a lot of research to make the leap from a rodent leaky gut study to human studies. It may take between 10 -20 years.

[hba24]

False alarm

[Boyce3600]

You talked in a previous post about resuming your fast walking. I believe you said you worked back up to 45 minutes at a time. Is there a way to judge what is actually "fast"? Is there a distance you try to cover in that length of time? Thank you.

[Hidden in reply to Boyce3600]

John Pepper's Parkinson's Disease Journey

Search the group for John's posts and comments.

3 - 4 miles estmated

youtu.be/_QVIdPo71gI(Not working as expected?)

[Hidden in reply to Boyce3600]

JohnPepper wrote:

Break from Fast Walking

Hi Royprop. I'm pleased to hear that you have started the walking again. I hope you can keep it up until you get to 1 hour. Then stick to that and just try to go faster and faster....

[beauxreflets]

In my understanding there are many contributing factors and possibilities; to a subsequent ill in idiopathic PD.

In my case, I feel quite sure that it arrived through a dual aspect of; The infection of the Central Nervous system via a bacterial virus (most likely via the gut) coupled with physical nerve tissue damage (via trauma) resulting in Spinal stenosis and Sciatica; that most likely contributed to more problems with nerve communication re-routed via the Vagus nerve,..., to cause mis-folded proteins in the brain cells, etc., as the disease progresses!

Come on, cures are not so far away.

[Roseyuk]

Sorry I think that is rubbish.. In the article..

Just saying.,

[PDDBSwife]

This is a difficult one. Bacteriophages are virus that replicate with bacterium (so not a Prion). Leaky gut refers to bacteriophages infecting ones own blood stream. But it's still comes down to propensity as to exactly what your disease du jour would be.

GailBailey Only a small percentage of PD is inherited, and those particular genes have been mainly identified (not that they can do much with that yet). There's a school of thought the gene mutations passed down and added to by each generation are the culprit for the decrepitude of our genetic propensity to develop known and unknown disease. A smorgasbord of corrupted DNA!