Sinermet plus: Sorry for being thick ! But... - Cure Parkinson's

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Sinermet plus

joe45 profile image
44 Replies

Sorry for being thick ! But what does the plus mean in sinermet plus ?

Thanks joe

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joe45 profile image
joe45
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44 Replies
soup profile image
soup

That's a good question. I know they re formulated Sinnemet a few years back so it probably means "Sinemet we can patent again and charge a lot of money for."

Perhaps I am too cynical. It works for most people and they must have added another ingredient.

joe45 profile image
joe45 in reply tosoup

Thanks for reply soup ..

Just a quick question soup do u know if u can take anxiety meds with pd meds ?

soup profile image
soup in reply tojoe45

I don't know for sure but have you timed your most anxious periods? Sometimes they coincide with wearing off and that would suggest the the wearing off needs addressing before adding anything else in.

I also spoke to a leading doctor in London at a conference about anxiety and he said that 'on ' anxiety can be treated with an anti depressant and talking therapies.

Get your docs and Parkinson's nurse on to this as soon as you can.

joe45 profile image
joe45 in reply tosoup

Hi,

I get most anxious when I'm up and Abt its cause I've had 8 falls at home and I feel I have to hold onto things around the house for the fear of falling but that can make u fall too im making myself weak cause of sitting down a lot

soup profile image
soup in reply tojoe45

Joe, I'm not surprised you are getting anxious but you need to break the cycle somewhere. I have a few suggestions but you can tell me to butt out if they don't suit.

First of all you need to make your home 'bomb proof' by inviting in an occupational therapist to do a review of your surroundings and the way you use the space and get yourself around.

Then your need meds or a therapist who can help you with the remaining anxiety.

At the same time as that you could do with some reason to go out, perhaps using some equipment at first to build your confidence. A frame or two hiking poles often help.

The home is sometimes the worst place to move around because it can get cluttered with 'stuff' such as furniture etc. Going out will help you build stride length again and a physio's visit would help build on that even more.

Do you go to any exercise classes or support groups which you could build into a routine?

joe45 profile image
joe45 in reply tosoup

Thanks for ur reply ,

Yeah it's knocked my confidence badly and I often get upset on a daily basis cos ive let it win ! I had reflexology yesterday and she is like my friend now, she would anything to help me , she spoke to nurse for me yesterday abt the anxiety , cause I was tearful couldn't speak , so I'm waiting to c what they come up with ..

I have been referred for a physio therapist to see me and I'm going to take up hypnotherapy again ..

Funny enough ive just brought a walker to build my legs up just so Ive got something to hold onto , i go on exercise bike and treadmill

No don't go to groups im not confident. To go by myself !

It is true what they say tho the more u fear and hold on to things you are bound to fall !

joe45 profile image
joe45 in reply tosoup

Thanks for ur reply ,

Yeah it's knocked my confidence badly and I often get upset on a daily basis cos ive let it win ! I had reflexology yesterday and she is like my friend now, she would anything to help me , she spoke to nurse for me yesterday abt the anxiety , cause I was tearful couldn't speak , so I'm waiting to c what they come up with ..

I have been referred for a physio therapist to see me and I'm going to take up hypnotherapy again ..

Funny enough ive just brought a walker to build my legs up just so Ive got something to hold onto , i go on exercise bike and treadmill

No don't go to groups im not confident. To go by myself !

It is true what they say tho the more u fear and hold on to things you are bound to fall !

soup profile image
soup in reply tojoe45

Joe, Where are you in the world? It's the USA isn't it?

joe45 profile image
joe45 in reply tosoup

Hi soup,

No I live in London

soup profile image
soup in reply tojoe45

Good the support is very good in England. Have you found the Parkinson's UK website? There's a lot of help through them. PM me if you want to carry on with this conversation privately, but perhaps other people can continue to post what helped them on this thread. There is somebody on here that is in a non Parkinson's UK sport group in London too. Perhaps if you can say if rough

Y where you are he/she could tell you more about the group.

joe45 profile image
joe45 in reply tosoup

Hi ,

Yeah I'm on Parkinsons U.K.

I just need to get over this fear of falling cause i fell again yesterday in my bedroom cause I fell there before so soon as I get near the doorway my legs go all stiff through nerves and I hestitate and try to hold on to the end of bed and fall if I didn't think Abt it i would not fall x it sounds silly I know x

joe45 profile image
joe45 in reply tosoup

Hi ,

Yeah I'm on Parkinsons U.K.

I just need to get over this fear of falling cause i fell again yesterday in my bedroom cause I fell there before so soon as I get near the doorway my legs go all stiff through nerves and I hestitate and try to hold on to the end of bed and fall if I didn't think Abt it i would not fall x it sounds silly I know x

soup profile image
soup in reply tojoe45

Have you had an occupational therapist out to watch you and give you some ideas? They area very good.

joe45 profile image
joe45 in reply tosoup

Hi,

No they said physio therapist be better for me ...

soup profile image
soup in reply tojoe45

Ok, have you managed to get an appointment?

joe45 profile image
joe45 in reply tosoup

Not yet , they take a while .. I'm having tapping today for my fear of falling ! Sinermet plus is much better than madopar !

quirkyme profile image
quirkyme in reply tojoe45

PwPD have to keep moving. But then so do all people who are getting older. Exercise is neuroprotective, that is, it's the one thing that helps slow the progression of PD. Use it or lose it. Do LSVT-BIG training or go to physical therapy that is used to working with PD patients. Oftentimes getting motivating is the issue. In which case, work on finding hope and your attitude. Good luck.

joe45 profile image
joe45 in reply toquirkyme

Hi thanks for reply ,

I wish I hadnt been so scared after falling then I'd be a bit stronger , I will get their if I can get through the fear ive got to im getting married nov 3rd !

quirkyme profile image
quirkyme in reply tosoup

my husband takes Cytalopram as an antidepressant and it's improved both mood and functioning markedly. He's not anxious so much as overly worried at times about things he kind of fixates on. Usually I can redirect him or we'll do a reality check and he can notice and address this thinking better.

It makes sense that if dopamine is low in people with PD that sometimes (often?) other neurotransmitters such as serotonin need to be attended to.

soup profile image
soup in reply toquirkyme

That was what the consultant in London recommended too.

I know people can be dead against anti depressants but my opinion is that if I was in a hole I would rather somebody gave me a ladder than teach me to climb.

Once I'm out of the hole that is depression I could learn to climb in case there is a next time. Talking therapies are like the climbing lessons to me.

quirkyme profile image
quirkyme in reply tosoup

as a caregiver, I have worked with people with depression for years and see it as a medical issue, a physical illness (it's "Not in your Head!!!!). Not enough serotonin. Anti-depressants work for many people -- those with PD and those with other conditions.

I totally agree about combining antidepressants with talk therapy. They work together with the sum greater than the two separately.

If people feel there is a stigma to taking antidepressants, they need to reframe their thinking. It's just a medication, just like PD meds. It meets a need in the body. Our bodies make less of the essential neuro-chemicals as we age and this is just a replacement. If people judge you for taking anti-depressants or you judge yourself, well, that can be worked through. Try taking a trial dose for 6-8 weeks and notice the difference (if any).

PD patients need to monitor mood as well as everything else. And just getting out of the house can lift a person's mood, no matter what, if any conditions they have.

joe45 profile image
joe45 in reply toquirkyme

Yeah I had citalopram once before I was dx cause doc thought i depressed instead I had pd ..

Anyway it didn't really agree with Me ...

cabbagecottage profile image
cabbagecottage

I have often posted the fact that in my husband case he appears to be worse an hour after taking his Sinemet , He becomes slower and switched off , it can take three hours to see him come back and then it's almost time for the next tablet . He generally takes them four hourly .

cabbagecottage profile image
cabbagecottage

He has recently come off the neupro patch and is better off it .

Someone did mention the fact that the MEDS can flood the brain . We have reduced to the lower dose. Everybody is so different

joe45 profile image
joe45 in reply tocabbagecottage

Hi thanks for reply ,

That's what ive just come off neupro but just wearing a 2 mg patch , I also just changed meds to sinermet plus 100/25 but take half tab , my anxiety is due to me having 8 falls in my house ive now become so fearful it's giving me anxiousness ,and it's making it hard to walk round cause im getting weak legs cause Im sitting too much

quirkyme profile image
quirkyme in reply tojoe45

you may be anxious for fear of what is ahead for you. That wears away one's self-confidence. But know that you can recover abilities that you thought were lost for good. Balance and maintaining stability are ongoing tasks for many. They can usually be improved. My husband goes through times of fearing that he will fall (and does). He loses confidence or something is off (meds, timing of them, the cold weather coming on, stresses).

What will help you regain confidence? For him it's walking every day and stretching before that. We thought he could only walk slowly but his PT showed him that he still has the ability to walk and walk fast. We find 'work arounds' for the nerve connections that have conked out. It can be done!!!

joe45 profile image
joe45 in reply toquirkyme

Thanku for reply , yeah I love going out if i can strengthen myself ill be more confident to get abt again ..

quirkyme profile image
quirkyme in reply tocabbagecottage

some people are really sensitive to meds. If you know that you can start off on half or a quarter patch, I think.

horsplay profile image
horsplay

I googled it and the only difference I can find is that the plus is the same thing as regular sinemet. It looks as if sinemet has 3 different combinations/strengths of carbidopa-levidopa and the plus has a fourth. The fourth being the 25/100 combo. So that's the only thing that I could find. Other than that, I would ask your pharmacist.

michaela13 profile image
michaela13

Joe, how are you? I haven't talked to you in a while. I got a prescription for the LDN (low dose naltrexone). Can't wait to start it. Sure hope it helps.

michaela13 profile image
michaela13

Joe, how are you? I haven't talked to you in a while. I got a prescription for the LDN (low dose naltrexone). Can't wait to start it. Sure hope it helps.

joe45 profile image
joe45 in reply tomichaela13

Hi michaela let me know how u get on ?

isis6361 profile image
isis6361

The plus is the combined two ingredients that enable more ldopa to be carried to the brain and to prevent breakdown of the dopamine to occur only in the brain.

joe45 profile image
joe45 in reply toisis6361

Hi, thanku

PatV profile image
PatV

It's basically sinimet.

isis6361 profile image
isis6361 in reply toPatV

All the sinemets are very different in the way they absorb in the gut. That's why not only are they different strengths they are also different chemical make ups. That's why sinemet plus us calked that.

joe45 profile image
joe45

Oh right thanku ..

ShakeDaddy profile image
ShakeDaddy

I have been on Sinimet 25/100 2tabs 3x day. It helps to relax and help my ontime as well as off. also take Ativan (Lorazepan) 1mg. dailyx2. Really helps me to feel better emotionally as well as an antidepressant. Also take Lamotrigine 25mg. 2x2 pills daily . Latter helps greatly with "lockjaw" while trying to speak, stammering and stuttering too. After being dx in 2001 I am doing surprisingly well. Still bowl 2x week and walk and do yardwork too. Hope this may have helped someone along the line .

joe45 profile image
joe45 in reply toShakeDaddy

Hi, shakedaddy

Thanks for yr reply, yes thanku that has helped and it's nice to hear yr still doing well ..

How long does it take for ur sinermet to kick in ?

Thanks joe

ShakeDaddy profile image
ShakeDaddy in reply tojoe45

I can usually feel better within an hour of taking my meds and if I keep on schedule, it maintains evenly most of the day. used to be on artane but my neuro took me off. it gave me hand tremors that I never had before. also i am in the USA hope this helps some one along the line . SD.... P.S. I have been on the Sinimet for 12 yrs with only on increase in doseage.

joe45 profile image
joe45 in reply toShakeDaddy

Hi thanks for reply,

yeah mine takes abt an hour or sometimes 30 mins , you seem to be doing well , that's great to hear !

joe45 profile image
joe45 in reply toShakeDaddy

Hi thanks for reply,

yeah mine takes abt an hour or sometimes 30 mins , you seem to be doing well , that's great to hear !

Pete-1 profile image
Pete-1

I can't see any difference. Only looked while half a sleep tho.

joe45 profile image
joe45 in reply toPete-1

Oh right thanku ,..

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