Ibrutinib,

[JJSI]

i have some pills of ibrutinib which expiration date is close, can they be used after the date of expiration and for how long, happy new year.

[DriedSeaweed]

If you lock your post you may get more replies.

I think the first major consideration is how well you took care of them. Were they in a humid environment like the bathroom or were they in a temperature and moisture controled area of your home?

In general, medical professionals will probably advise controlled disposal at a pharmacy.

That said… I keep things longer than expiration all the time just in case. Never know if the world will fall apart one day. After 2-3 years I will toss things since by then I usually have replacements. I will likely have leftover venclexta. I’ll hang onto them for a while but after a certain point I expect to be resistant to it. I would toss it by then.

Be reasonable. If they were kept in a medicine cabinet (terrible invention) in a bathroom that frequently gets wet and humid I wouldn’t bother.

[JJSI in reply to DriedSeaweed]

thank you, happy new year.

[lankisterguy Volunteer]

Hi JJSI,

Here are some informative articles for your reading (enjoyment or confusion):

ncbi.nlm.nih.gov/pmc/articl...

propublica.org/article/the-...

sciencebasedmedicine.org/ar...

"Medication's potency gradually decreases starting from the moment of its manufacture. This process is not in any way spontaneous after the expiry date.

Expired drugs have not necessarily lost their potency and efficacy. The expiration date is only an assurance that the labeled potency will last at least until that date. Ongoing research shows that stored under optimal conditions, many drugs retain 90% of their potency for at least five years after the labeled expiration date, and sometimes longer. Even 10 years after the expiration date many pharmaceuticals retain a significant amount of their original potency.2

Solid dosage forms, such as tablets and capsules, are most stable past their expiration date. Drugs that exist in solution or as a reconstituted suspension may not have the required potency if used when outdated.

The best evidence of acceptable potency of the medications beyond their expiration date is provided by the Shelf Life Extension Program (SLEP) undertaken by the FDA for the Department of Defense. The aim of the SLEP program was to reduce medication costs for the military. SLEP has found that 88% of 122 different drugs stored under ideal conditions should have their expiration dates extended more than 1 year, with an average extension of 66 months, and a maximum extension of 278 months.3 Certain medications have a narrow therapeutic index and little decreases in the pharmacological activity can result in serious consequences for patients. Monoclonal antibodies should be included in this group. These drugs should not be used beyond the expiry date"

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Len

[JJSI in reply to lankisterguy]

Thank you very much for your information, happy new year.