Anyone know any thing about clinical trial BMF-219 a covalent,mein inhibitor

[Osprey69]

I have been in Loxo clinical trial at MSK for 40 mo and have begun to slowly progress. I have been exploring options for next treatment plan.Have been seen at NIH and offered their clinical Nurix trial (degrader) . At vs with my local hematologist (Va Cancer Sp) she referred me to their research dept which came up with this clinical trail. I have appt to discuss on Tuesday but would appreciate any thoughts from this group. This was a new approach for me-a covalent mein inhibitor ( attempting to interfere/degrade MYC responsible for sustain tumor growth) This is all very much above my pay grade but trying to understand. Thank for any thoughts. Fran

[Jooby59]

Hi. I have been on the NURIX trial since end of November and it is working really well. Did you decide to go on it? x

[Osprey69]

mind me asking which specific Nurix trial I qualified for one and FDA closed it two days after I quailed said they have to change manufacturing process 🤨 and no one seems to know how long this will take. Meanwhile in strange set of circumstances- had been on Loxo started in Phase 1A 6/19 did fine controlled my numbers was not allowed to move over to combination so in Aug/23 numbers started to increase,felt fine , nodes unchanged however research team felt I was progressing 😠. I am now outside trial, seeing team every 3 mo, still receiving drug. I will go back end of April and see what my labs look like. Dr Thompson (MSK) feels that a degrader would work looking at results of my Impact Testing and my mutations. She is suggesting Bigene ‘s degrader and they have trial there in Phase 2?? Sorry for such long story-glad you are doing ok-many side effects? How are your numbers if you don’t mind me asking. Fran