obinutuzumab + acalaibrutinib + Venitoclax

[theoptimistduo]

Is someone else in the community taking this combination of treatment altogether?

My husband has been having multiple issues sver since he has started this combination

Fact is, he hasn’t been able to take all of them together at a strech due to some side effect or the other

Has someone else faced these issues or even taken this combination at first?

[AussieNeil Partner Administrator]

I see that you have posted separately about this here: healthunlocked.com/cllsuppo...

You will get more responses to your posts if you make them private to this community per:healthunlocked.com/cllsuppo...

There have been two clinical trials of this A+V+O combination; Dana-Farber Cancer Institute and a large international one by AstraZeneca that I completed in January 2021. Hence there's a reasonable number of members who have been on or are on this trial.

I reached uMRD and my haemoglobin, neutrophil and platelet counts are the best they've been since before I was diagnosed. I has a difficult start due to delays beginning treatment.

Thank you for completing your bio to share your husband's extensive treatment history. You ended you bio "We have taken opinions from his main CLL specialist and one more renowned doctor of India

One says we must start with Obinutuzumab + Calquence + venitoclax

Other says Bone marrow transplant is the only retort."

I note that he is being treated for invasive aspergillosis and has been heavily treated for CLL and even Richter's Transformation. I'm also not sure how many of his previous health problems are still current. It's also not clear to me where your husband is in his treatment AVO treatment. Is he going through his venetoclax ramp up?

We can't give medical advice, but have you asked the specialist who recommended the current treatment for his CLL, how long his remission is expected to last? He has age on his side if decides to have a bone marrow transplant and it can cure CLL.

Neil