Had 5 vaccines, what abt 6th?

[Research123]

I had my last vaccine in March, the 5th - anyone getting extra boosters now? Can we do that in uk and if so, how?

[Walkingtall62]

Hi, I have had four jabs in total to date. I have recently received an email from the NHS telling me how to book my next booster, or go to local drop in pharmacies - list given when you enter your post code. I understand that my GP surgery is also about to start vaccinations, but don’t know when. Hope this helps

[Hilo13 in reply to Walkingtall62]

hi yes had it last week usual side effects for 24 hours all gone now good luck

[niceone01]

Having my 6th on Friday. Near the front of the queue for once.😀

[mrsjsmith]

Yes I booked mine on the NHS website. If you can’t find it there are links on the various blood charities. My text came last Wednesday

nhs.uk/get-vaccination

Colette

[Research123 in reply to mrsjsmith]

Thank you. I've booked mine for Wednseday using that link

[uide3095]

Yeah just got the message to book my 6th !

[Pekingese]

I’m having my 6th vaccine in 2 weeks, I’m in the UK I received a message on my phone, they are also sending letters out.

[Indolent]

Yes, I sometimes wonder if there is any possibility of an "exhaustion" side effect of too many of the same vaccinations. Does our immune system begin to ignore and simply overlook the stimulation and fail to mount an immune response?

[Jmiah717 in reply to Indolent]

I don't want to go all conspiracy theory here, but a doctor out if Japan is raising this exact concern.

[Davidcara in reply to Indolent]

I have had 5 jabs and feel my immune system ignored all of them

[kitchengardener2]

I booked mine for 1st October via NHS link, could have had it earlier but had flu jab booked for 29th September and didn't want them too close or together.

[camper2]

I was due flu jab on Friday at local Boots. Went in and was offered Covid jab too (Moderna bivalent vaccine). That was my 6th.

As usual I ran a temperature that night and didn’t leave my bed Saturday I felt so awful (felt like flu). Still wobbly but ok yesterday (Sunday).

Seriously considering not having any more Covid vaccines, I don’t produce antibodies so what’s the point? Is it just a waste of money and pain to vaccinate people like me (on Acalabrutinib)? We should be on Evusheld!!

[Davidcara in reply to camper2]

apparently there is the minuscule chance you will get some T cell benefit from it. So whatever that minuscule possibility is worth to you.

[SofiaDeo in reply to Davidcara]

"T cell immunity may be critical for long-term protection by COVID-19 vaccines" so I think it's turning out to be rather significant, according to this Aug 22 issue of Science:

science.org/doi/10.1126/sci...

[AussieNeil Administrator in reply to Davidcara]

Don't confuse difficult to measure with of minuscule benefit. A recent study found ~80% of CLL patients generated a T cell response (how much was annoyingly not stated). The problem is that we don't yet have the tools to easily measure T cell response; it can only be done in specialised labs. B cell responses can be assessed by a mass produced testing kit (LFT or RAT testing) and there are plenty of specific lab tests for different antibody responses.

That's why you see lots of studies on antibody responses from B cells, but very few on T cells. If we don't have spike neutralising antibody coverage, for example, then our bodies enter the next phase of the infection - out body cells becoming infected and turned into virus producing factories that flood our bodies with viruses. That's when we need T cells that can identify and destroy infected body cells if we are to avoid a full on COVID-19 infection.

Current research is a bit like a drunk trying to find his dropped car keys at night under the streetlight light, because it's easier to search there.

Neil

[Davidcara in reply to AussieNeil]

I believe people with CLL, and especially those on BTKi have poor response to vaccines. Antidotally, I keep hearing CLL folks with multiple covid vaccines are not fairing as well as those with intact immune systems during covid infection. Maybe I misspoke or exaggerated, should not be minuscule, should be less than optimal T Cell response. I wonder whatever happened to the Lymphoma and Leukemia Society TCell study? Just hard to be objective, or feel good about any vaccination after dealing with covid for the last 50 days. Now our US President says the pandemic is over. He also said look around no one is wearing a mask and they seem to be doing ok. So frustrating.

Here’s the link to study information released today For me, even though the data is unclear, not expecting much from the vaccines, that includes antibody and T cell response

lls.org/news/study-leukemia...

[Eric70]

Having my 6th Covid Jab tomorrow.

[Michaeljohn50]

Had my 6th last Thursday, Moderna Bivalent, following a text from the NHS. Slightly sore arm but otherwise fine. The first 5 did not produce antibodies so I am not hopeful! The incredible deception, incompetence and delay around procuring Evusheld in the UK leads me to think that Christmas 2022 will be our third one isolated and separated. Trying hard to find an upside.

Best wishes to all,

Michael

[Mtk1]

yes, I also received text and email to book, and also list of walk in centres with no appointment needed, but went Saturday morning to a walk in centre only to be told they are not accepting walk ins only appointments, all the people there were turned away some travelling quite a distance, so if anyone is thinking of doing walk in please check before going. Dave.

Ps booked online for 5th jab this Wednesday.

[CLLmoxie]

Why? They don’t work.

[1962jns in reply to CLLmoxie]

not only don’t work but can be harmful.

[AussieNeil Administrator in reply to 1962jns]

CLLmoxie and 1962jns, given CLL specialists recommend that we should have COVID-19 vaccinations, where is your evidence that their recommendation is wrong?

Antibody response for us is not likely to be as good as seen in healthy folk, but a recent study found that 80% of those with CLL had a T cell response.

Certainly vaccinations can be harmful, but it's a much lesser harm than a COVID-19 infection.

I know that CDC statistics are not that trusted nowadays, but what about Switzerland? Other countries show similar results.

Neil

Switzerland unvaccinated death rate is ~12 times full vax and ~36 times full vax + boost.

[1962jns in reply to AussieNeil]

Given the right medication when diagnosed with covid is much safer then any vaccine. The problem in my country is getting the life saving medication

This has been political from the start.

[Research123 in reply to 1962jns]

I think for some, reaction to the vaccine is emotional. The stats though suggest that generally speaking they are a very good thing. Being 10 times less likely to end up in hospital is definitely a plus in my eyes.

[AussieNeil Administrator in reply to Research123]

I think you are referring to this news article or similar, from January 2022:

According to a new study involving over 45,000 patients, most of the adverse reactions people experienced after having a COVID-19 vaccination could be due to the nocebo effect.

The nocebo effect is a bit like the 'evil twin' of the placebo effect, occurring when a patient experiences negative side effects to a treatment because they're expecting to.

In a meta-analysis of 12 randomized, placebo-controlled clinical trials, a team of researchers at Beth Israel Deaconess Medical Center (BIDMC) in Boston found that up to 64 percent of adverse effects may be attributable to this kind of worry.

sciencealert.com/nearly-two...

[Fran57]

Hello. Yes, Paul also had a text, but we’re hoping 🤞🏻to move on Thursday so, once it’s definite, he will book in our new county 😉

Stay safe,

Fran 😷

[andyfurks]

About to arrange No 6 along with flu vaccine - got an email and a txt from the NHS

[tkstat]

I had AstraZeneca 1 and 2. Then Booster 1 and 2. Just had Bivalent booster. All good. COVID free thus far.

[mikec11]

😬 I’m still recovering from my 5th last Thursday. Previously had 4 Pfizer, this was my first Moderna BA 4/5 Bivalent.

I don’t think I could willingly do this again. I can’t imagine if mRNA is the future of delivery systems for Flu, RSV, etc… and immunotherapy? For me the side effects have been bad. Maybe I have T-Cells that just can’t stand it 🤷🏻‍♂️

[SofiaDeo in reply to mikec11]

have you had severe SE from all of them, or just 1 brand? Moderna contains tromethamine, which has been known to cause muscle irritation if extravasated. Some people can develop allergies to it, also. Pfizer doesn't have large chemicals like tromethamine to potentially cause reactions IMO. Instead it has these large lipid structures, which I do not think cause antigenic reactions. I could be wrong, I haven't looked them all up.

[mikec11 in reply to SofiaDeo]

Thank you for this. My first 4 were Pfizer and only this one was the Moderna Bivalant. Very similar SE pattern for all them, with the Moderna being the most severe. So your thoughts make sense. The amount of swollen Lymph Nodes makes me think that my immune response is the culprit.

I don’t seem to have as a severe response to Flu or my previous Pneumovax and Previnar 13 or my Shingrex jabs.

Funny thing is this time it is almost like what I would perceive B symptoms would eventually be like when that day finally comes. Fortunately I am progressing slowly in W&W!

[SofiaDeo in reply to mikec11]

I remember reading that 1 of the earlier vaccines had mmm twice? the genetic material stimulating the immune reaction, and had more side effects. Thought to be because there was more immune stimulating material compared to the others. IDK if or to what exent this might play in this newer booster.

I haven't reacted strongly to vaccines except the pnemonia one.

[AussieNeil Administrator in reply to SofiaDeo]

Moderna had ~twice the volume of the Pfizer vaccination in the initial vaccination series, but it was reduced in the booster. I had 2x Pfizer - hardly felt the injections. Reactions (arm discomfort) were less than from the quad flu shot. Moderna booster arm discomfort was more like that from the flu. Thankfully for me, the COVID-19 vaccinations only resulted in a tender upper arm for a day or so.

Neil

[SofiaDeo in reply to AussieNeil]

I am getting Covid booster this Saturday (bloodwork Thursday so as not to confound blood results). Flu shots are only available in pharmacies here right now, I will wait until I can go into the doc's office for mine, they think next month. I think this is #5, I missed one earlier this summer. Now that I am out a tiny bit more, I am wanting whatever potential protection I may be able to muster.

[AussieNeil Administrator in reply to SofiaDeo]

At least with flu shots, if we've had them prior to treatment, you get memory B cell stimulation, so the flu shots should boost antibody production. I do hope we see combined flu+corona virus mRNA vaccines to provide better protection from coronavirus colds, the flu and the SARS coronaviruses. Even the former can kill when they trigger pneumonia.

Neil

[Gardengirl44]

not going to lie… I’m spooked . My lymph nodes erupted after the first covid shot . I’ve gotten 4 total . Not sure what I’m doing yet but I work in healthcare - so need to figure it out soon .

[AussieNeil Administrator in reply to Gardengirl44]

Did your lymph nodes subsequently return to their normal size? I would consider temporarily enlarged lymph nodes to be an encouraging sign than if they didn't enlarge.

Swelling nodes is how your body is producing lots of lymphocytes to mature into memory B cells and plasma cells.

Have you ever had your antibody response to past vaccinations measured? That might help with your decision.

Neil

[Gardengirl44 in reply to AussieNeil]

hi Neil!! No it was no when I was diagnosed. They never went down to regular size. yes I did get tested after my second shot and I had tons of antibodies.