3 IGHV Mutation Rate

[tms99532]

Why my report have three IGHV mutation rate

IGH LEADER

1 Dominant sequence at 72.5% (IGHV3-15_01, IGHJ4_02) productive sequence with mutation rate at 8%

IGH FRAMEWORK REGION 1 ( FR 1 )

1 Dominant seqence at57.6% (IGHV3-20_01,IGHJ6_03 ) unproductive sequence with mutation rate at 2.6%

2 Dominant sequence at 32% (IGHV3-15_02,IGHJ4_02 ) productive sequence with mutation rate at 9.4%

Note All unassigned stereotyped subset

Is this well prognostic marker or not

[seelel]

Everywhere tested on the Ig is above 2% which is the cutoff point for mutation status.

You are therefore IgVH mutated which is the favourable bucket to be in.......

[annmcgowan]

Hi can you tell me what the cut off point for mutated is? Do you have to be 2% above that point to be mutated. My results are not so detailed. They say 97.9% some mutated and some borderline mutated, unequivocal.

Ann

[tms99532 in reply to annmcgowan]

I have three mutation rate 8 , 2.6 , 9.4

[tms99532 in reply to tms99532]

Detection by NEXT-GENERATION SEQUENCING ( NGS )

[tms99532]

Detection by NEXT-GENERATION SEQUENCING ( NGS )