New research on 400 CLL patients show which factors determine positive response to mRNA Covid-19 vaccine:

[RamOren]

Link to the paper:

haematologica.org/article/v...

[Davidcara]

Sort of shows what every other study shows. Those with immune deficiency respond poorly to safe covid vaccines. In addition, those with CLL are poor responders, especially if on treatment. What I do find interesting in the studies I have seen, there is never mention of how the CLL folks responded, if they in fact did respond. Meaning was it a robust, moderate, or week response. Was it 1.0, 2.0, 100.0, 2500.0, or some other number of spike protein antibodies. So if someone is counted as responding, was it a minuscule or robust response. I think I know what the answer to this could be; any response is considered positive. Keep the mask on folks.

[RamOren in reply to Davidcara]

If I understand it correctly, Figure 2 shows the values - but I could not figure out the scale. Probably it depends on the particular serological test. What I found interesting is the following statement (I wish it is will be true for all CLL patients): " During the course of the study and 3 months observation period post second

vaccination dose we had only 3 patients out of 400 patients who developed COVID-

19 infection following vaccine. One patient acquired the infection between the first

dose and the second dose (3 weeks) and two patients after 14 days and 24 days after

the second dose, all three of them recovered uneventfully."

[bennevisplace in reply to RamOren]

I think this paper is useful but needs some editing: the Abstract, the Introduction where there seems to be a page missing, and explanation of how they measured "anti covid19 RBD-IgG titer" the x-value in Fig 2.

Fig 2 does not apply to all patients in all centers, but to a subset of 45 patients at Sheba medical center. It would be difficult to normalise the results of 4 different IgG antibody tests, so the other 3 test results are reported above or below cutoff value for the test. That's my interpretation anyway.

My main gripe with this study (and others) is that Abs were measured between 2 and 3 weeks after 2nd vaccination, OK for immunocompetent subjects but that interval may be too short for CLL patients. If a weak response takes 2 or 3 weeks longer to register, this could bias the whole study.

[micg]

I have taken the Covid vaccine and have CLL. I wonder however, if anyone ever investigated if the mRNA vaccines and potential deleterious affect on CLL in general. Especially in changing antigen markers which affect treatments.