prolymphocytic

[lindalou5]

new report and lymphs are 81 and a new word for me 'prolymphocytic'. Googled and sounds scary. Anyone, help understanding this?

[Cllcanada Top Poster CURE Hero]

Have you been diagnosed with PLL? It's a rare B or T cell leukemia

A small percentage is common in CLL...

leukaemiacare.org.uk/suppor...

uptodate.com/contents/b-cel...

~chris

[lindalou5 in reply to Cllcanada]

It says 10%..so that is normal for CLL then? Diagnosed last fall with CLL, so did not know if this was something new to get upset about or go back to the normal anxiety.

[Cllcanada Top Poster CURE Hero in reply to lindalou5]

I have no idea what the percentages are... I have noted them on my report for year's...if concerned call your doctor...

~chris

[lindalou5]

thanks for the info

[bbreeland]

I have them also on my CBC and I think it may be relatively common. If they move to 55% it is considered PLL which is very rare as Chris said. I would still contact my doctor and ask for an explaination. Are you seeing a CLL specialist? What is your genetic profile, if you know it.

[lindalou5]

I do not know for sure what part that is..I do know that I have 11q and 13q deletion. results below from Oct 2017: The result is abnormal and indicates an 11q deletion in

23.5% of nuclei. In addition, a 13q deletion of one

chromosomes 13 and three copies of the MDM2 gene region (at

12q15) were observed in approximately 15% of nuclei.

In CLL, and 11q deletion has been associated with an

unfavorable prognosis (Parikh et al., Blood 127:1752-1760,

2016; Van Dyke et al., Brit J Haematol 173:105-113, 2016).

And if this wasn't discouraging enough, now having seen the 10 % Prolymphotytes on My Chart, it all seems so scary.

[lindalou5]

This is the pathology report from my tonsilectomy:

DIAGNOSIS:

BILATERAL TONSILS, TONSILLECTOMIES

--MALIGNANT LYMPHOMA, SMALL LYMPHOCYTIC TYPE

M-9670/3

GROSS: The specimen in a container labeled "tonsils" consists of two

relatively symmetric tonsils, 4.6 x 4.7 x 2.4 cm in aggregate. These have

the normal crypt architecture without areas of ulceration or mass lesion.

A section from each is submitted in A-1.

MICROSCOPIC EXAMINATION: Performed. The tonsils are occupied by a diffuse

population of small mature-appearing lymphocytes with small nucleoli.

There are collections of moderately sized to large lymphocytes with

slightly more cytoplasm. These give a slight pale appearance to these

zones on a low power view. Immunohistochemical stains show that these

cells co-express CD5, CD20 and CD23. They express PAX5 but do not express

the T-cell marker CD3 or the Mantle cell lymphoma marker Cyclin D1.